Prognostic Value of β-Catenin and L1CAM Expressions in Type I Endometrial Carcinoma
The aim of this study is to evaluate the expression of β-catenin and L1CAM in the type I of Endometrial Carcinoma. This study was an analytical study with a cross-sectional design using 49 samples of type I Endometrial Carcinoma. Immunohistochemical method was used to evaluate the expression of β-ca...
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| Veröffentlicht in: | Asian Pacific Journal of Cancer Prevention 2023-04, Vol.24 (4), p.1413-1417 |
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| container_title | Asian Pacific Journal of Cancer Prevention |
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| creator | Manule, Yolanda Miskad, Upik Anderiani Masadah, Rina Nelwan, Berti Cangara, Muhammad Husni Mardiati, Mardiati |
| description | The aim of this study is to evaluate the expression of β-catenin and L1CAM in the type I of Endometrial Carcinoma.
This study was an analytical study with a cross-sectional design using 49 samples of type I Endometrial Carcinoma. Immunohistochemical method was used to evaluate the expression of β-catenin and L1CAM related to two significant prognostic parameters i.e., lymphovascular space invasion (LVSI) and metastases event of type I Endometrial Carcinoma samples.
From all samples collected, based on the presence of LVSI, there were 17 cases (34.7%) with LVSI and 32 (65.3%) no LVSI. Among them, there were 13 cases that included lymph node or omental samples in type I Endometrial Carcinoma, 5 (38.5%) cases of metastasis, and 8 (61.5%) cases that did not metastasize. The statistical results showed that there was a significant correlation between β-catenin and L1CAM expressions examined from tumor cells with lymphovascular space invasion and the presence of metastases in the type I Endometrial Carcinoma (p |
| doi_str_mv | 10.31557/APJCP.2023.24.4.1413 |
| format | Article |
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This study was an analytical study with a cross-sectional design using 49 samples of type I Endometrial Carcinoma. Immunohistochemical method was used to evaluate the expression of β-catenin and L1CAM related to two significant prognostic parameters i.e., lymphovascular space invasion (LVSI) and metastases event of type I Endometrial Carcinoma samples.
From all samples collected, based on the presence of LVSI, there were 17 cases (34.7%) with LVSI and 32 (65.3%) no LVSI. Among them, there were 13 cases that included lymph node or omental samples in type I Endometrial Carcinoma, 5 (38.5%) cases of metastasis, and 8 (61.5%) cases that did not metastasize. The statistical results showed that there was a significant correlation between β-catenin and L1CAM expressions examined from tumor cells with lymphovascular space invasion and the presence of metastases in the type I Endometrial Carcinoma (p <0.05).
This study suggest that the positive expression of β-catenin together with L1CAM can participate in the development of tumor cells in type I Endometrial Carcinoma, in its ability to involve lymphovascular space invasion, and metastases to other sites. Our results indicate that both of β-catenin and L1CAM are prominent biomarkers for the prognosis of type I Endometrial Carcinoma.</description><identifier>ISSN: 2476-762X</identifier><identifier>ISSN: 1513-7368</identifier><identifier>EISSN: 2476-762X</identifier><identifier>DOI: 10.31557/APJCP.2023.24.4.1413</identifier><identifier>PMID: 37116166</identifier><language>eng</language><publisher>Thailand: West Asia Organization for Cancer Prevention</publisher><subject>beta Catenin ; Carcinoma, Endometrioid - metabolism ; Cross-Sectional Studies ; Endometrial Neoplasms - pathology ; Female ; Humans ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; Neural Cell Adhesion Molecule L1 - metabolism ; Prognosis</subject><ispartof>Asian Pacific Journal of Cancer Prevention, 2023-04, Vol.24 (4), p.1413-1417</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-1980-395X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352722/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352722/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37116166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manule, Yolanda</creatorcontrib><creatorcontrib>Miskad, Upik Anderiani</creatorcontrib><creatorcontrib>Masadah, Rina</creatorcontrib><creatorcontrib>Nelwan, Berti</creatorcontrib><creatorcontrib>Cangara, Muhammad Husni</creatorcontrib><creatorcontrib>Mardiati, Mardiati</creatorcontrib><title>Prognostic Value of β-Catenin and L1CAM Expressions in Type I Endometrial Carcinoma</title><title>Asian Pacific Journal of Cancer Prevention</title><addtitle>Asian Pac J Cancer Prev</addtitle><description>The aim of this study is to evaluate the expression of β-catenin and L1CAM in the type I of Endometrial Carcinoma.
This study was an analytical study with a cross-sectional design using 49 samples of type I Endometrial Carcinoma. Immunohistochemical method was used to evaluate the expression of β-catenin and L1CAM related to two significant prognostic parameters i.e., lymphovascular space invasion (LVSI) and metastases event of type I Endometrial Carcinoma samples.
From all samples collected, based on the presence of LVSI, there were 17 cases (34.7%) with LVSI and 32 (65.3%) no LVSI. Among them, there were 13 cases that included lymph node or omental samples in type I Endometrial Carcinoma, 5 (38.5%) cases of metastasis, and 8 (61.5%) cases that did not metastasize. The statistical results showed that there was a significant correlation between β-catenin and L1CAM expressions examined from tumor cells with lymphovascular space invasion and the presence of metastases in the type I Endometrial Carcinoma (p <0.05).
This study suggest that the positive expression of β-catenin together with L1CAM can participate in the development of tumor cells in type I Endometrial Carcinoma, in its ability to involve lymphovascular space invasion, and metastases to other sites. Our results indicate that both of β-catenin and L1CAM are prominent biomarkers for the prognosis of type I Endometrial Carcinoma.</description><subject>beta Catenin</subject><subject>Carcinoma, Endometrioid - metabolism</subject><subject>Cross-Sectional Studies</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>Neural Cell Adhesion Molecule L1 - metabolism</subject><subject>Prognosis</subject><issn>2476-762X</issn><issn>1513-7368</issn><issn>2476-762X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkF1OAjEUhRujEUSXoOkGZuzvdObJkAkqBiMPaHxrOp0Wx0BLWjCyLRfimhxACT7dk5x85yYfAJcYpRRzLq7744dynBJEaEpYylLMMD0CXcJEloiMvB4f5A44i_EdIcZzwU9BhwqMM5xlXTAZBz91Pi4bDV_UbGWgt_D7KynV0rjGQeVqOMJl_xEOPhfBxNh4F2FbTNYLA4dw4Go_N8vQqBksVdCN83N1Dk6smkVz8Xt74Pl2MCnvk9HT3bDsjxJNBKeJZYXlihBrrVI011bruqC1NhnOFUeaMlYVrMIcE8FYznmNaI0Fq2hGi4Ii2gM3u93FqpqbFnTLoGZyEZq5CmvpVSP_N655k1P_ITGinAhC2gW-W9DBxxiM3cMYya1nufUsN54lYZLJjeeWuzr8vKf-xNIf7ph6tg</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Manule, Yolanda</creator><creator>Miskad, Upik Anderiani</creator><creator>Masadah, Rina</creator><creator>Nelwan, Berti</creator><creator>Cangara, Muhammad Husni</creator><creator>Mardiati, Mardiati</creator><general>West Asia Organization for Cancer Prevention</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1980-395X</orcidid></search><sort><creationdate>20230401</creationdate><title>Prognostic Value of β-Catenin and L1CAM Expressions in Type I Endometrial Carcinoma</title><author>Manule, Yolanda ; Miskad, Upik Anderiani ; Masadah, Rina ; Nelwan, Berti ; Cangara, Muhammad Husni ; Mardiati, Mardiati</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2753-f49f5a22fffaa38cfccd93dce618a50c344b94b1512744855d03d174b36399303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>beta Catenin</topic><topic>Carcinoma, Endometrioid - metabolism</topic><topic>Cross-Sectional Studies</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>Neural Cell Adhesion Molecule L1 - metabolism</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manule, Yolanda</creatorcontrib><creatorcontrib>Miskad, Upik Anderiani</creatorcontrib><creatorcontrib>Masadah, Rina</creatorcontrib><creatorcontrib>Nelwan, Berti</creatorcontrib><creatorcontrib>Cangara, Muhammad Husni</creatorcontrib><creatorcontrib>Mardiati, Mardiati</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manule, Yolanda</au><au>Miskad, Upik Anderiani</au><au>Masadah, Rina</au><au>Nelwan, Berti</au><au>Cangara, Muhammad Husni</au><au>Mardiati, Mardiati</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Value of β-Catenin and L1CAM Expressions in Type I Endometrial Carcinoma</atitle><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle><addtitle>Asian Pac J Cancer Prev</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>24</volume><issue>4</issue><spage>1413</spage><epage>1417</epage><pages>1413-1417</pages><issn>2476-762X</issn><issn>1513-7368</issn><eissn>2476-762X</eissn><abstract>The aim of this study is to evaluate the expression of β-catenin and L1CAM in the type I of Endometrial Carcinoma.
This study was an analytical study with a cross-sectional design using 49 samples of type I Endometrial Carcinoma. Immunohistochemical method was used to evaluate the expression of β-catenin and L1CAM related to two significant prognostic parameters i.e., lymphovascular space invasion (LVSI) and metastases event of type I Endometrial Carcinoma samples.
From all samples collected, based on the presence of LVSI, there were 17 cases (34.7%) with LVSI and 32 (65.3%) no LVSI. Among them, there were 13 cases that included lymph node or omental samples in type I Endometrial Carcinoma, 5 (38.5%) cases of metastasis, and 8 (61.5%) cases that did not metastasize. The statistical results showed that there was a significant correlation between β-catenin and L1CAM expressions examined from tumor cells with lymphovascular space invasion and the presence of metastases in the type I Endometrial Carcinoma (p <0.05).
This study suggest that the positive expression of β-catenin together with L1CAM can participate in the development of tumor cells in type I Endometrial Carcinoma, in its ability to involve lymphovascular space invasion, and metastases to other sites. Our results indicate that both of β-catenin and L1CAM are prominent biomarkers for the prognosis of type I Endometrial Carcinoma.</abstract><cop>Thailand</cop><pub>West Asia Organization for Cancer Prevention</pub><pmid>37116166</pmid><doi>10.31557/APJCP.2023.24.4.1413</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-1980-395X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free E- Journals |
| subjects | beta Catenin Carcinoma, Endometrioid - metabolism Cross-Sectional Studies Endometrial Neoplasms - pathology Female Humans Neoplasm Invasiveness - pathology Neoplasm Staging Neural Cell Adhesion Molecule L1 - metabolism Prognosis |
| title | Prognostic Value of β-Catenin and L1CAM Expressions in Type I Endometrial Carcinoma |
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