Prognostic Value of β-Catenin and L1CAM Expressions in Type I Endometrial Carcinoma
The aim of this study is to evaluate the expression of β-catenin and L1CAM in the type I of Endometrial Carcinoma. This study was an analytical study with a cross-sectional design using 49 samples of type I Endometrial Carcinoma. Immunohistochemical method was used to evaluate the expression of β-ca...
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Veröffentlicht in: | Asian Pacific Journal of Cancer Prevention 2023-04, Vol.24 (4), p.1413-1417 |
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Sprache: | eng |
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Zusammenfassung: | The aim of this study is to evaluate the expression of β-catenin and L1CAM in the type I of Endometrial Carcinoma.
This study was an analytical study with a cross-sectional design using 49 samples of type I Endometrial Carcinoma. Immunohistochemical method was used to evaluate the expression of β-catenin and L1CAM related to two significant prognostic parameters i.e., lymphovascular space invasion (LVSI) and metastases event of type I Endometrial Carcinoma samples.
From all samples collected, based on the presence of LVSI, there were 17 cases (34.7%) with LVSI and 32 (65.3%) no LVSI. Among them, there were 13 cases that included lymph node or omental samples in type I Endometrial Carcinoma, 5 (38.5%) cases of metastasis, and 8 (61.5%) cases that did not metastasize. The statistical results showed that there was a significant correlation between β-catenin and L1CAM expressions examined from tumor cells with lymphovascular space invasion and the presence of metastases in the type I Endometrial Carcinoma (p |
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ISSN: | 2476-762X 1513-7368 2476-762X |
DOI: | 10.31557/APJCP.2023.24.4.1413 |