Endoscopic Screening Program for Control of Esophageal Adenocarcinoma in Varied Populations: A Comparative Cost-Effectiveness Analysis

Guidelines suggest endoscopic screening for esophageal adenocarcinoma (EAC) among individuals with symptoms of gastroesophageal reflux disease (GERD) and additional risk factors. We aimed to determine at what age to perform screening and whether sex and race should influence the decision. We conduct...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2022-07, Vol.163 (1), p.163-173
Hauptverfasser:	Rubenstein, Joel H., Omidvari, Amir-Houshang, Lauren, Brianna N., Hazelton, William D., Lim, Francesca, Tan, Sarah Xinhui, Kong, Chung Yin, Lee, Minyi, Ali, Ayman, Hur, Chin, Inadomi, John M., Luebeck, Georg, Lansdorp-Vogelaar, Iris
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - epidemiology Barrett Esophagus - diagnosis Barrett’s Esophagus Cost-Benefit Analysis Cost-Effectiveness Analysis Esophageal Neoplasms Esophageal Neoplasms - epidemiology Female Gastroesophageal Reflux - complications Humans Male Mass Screening Middle Aged
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Zusammenfassung:	Guidelines suggest endoscopic screening for esophageal adenocarcinoma (EAC) among individuals with symptoms of gastroesophageal reflux disease (GERD) and additional risk factors. We aimed to determine at what age to perform screening and whether sex and race should influence the decision. We conducted comparative cost-effectiveness analyses using 3 independent simulation models. For each combination of sex and race (White/Black, 100,000 individuals each), we considered 41 screening strategies, including one-time or repeated screening. The optimal strategy was that with the highest effectiveness and an incremental cost-effectiveness ratio
ISSN:	0016-5085 1528-0012
DOI:	10.1053/j.gastro.2022.03.037