Fulminant echovirus 11 hepatitis in male non-identical twins in northern Italy, April 2023

Echovirus 11 (E11) has recently been associated with a series of nine neonatal cases of severe hepatitis in France. Here, we present severe hepatitis caused by E11 in a pair of twins. In one of the neonates, the clinical picture evolved to fulminant hepatitis. The E11 genome showed 99% nucleotide id...

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Veröffentlicht in:	Euro surveillance : bulletin européen sur les maladies transmissibles 2023-06, Vol.28 (24), p.1
Hauptverfasser:	Piralla, Antonio, Borghesi, Alessandro, Di Comite, Amelia, Giardina, Federica, Ferrari, Guglielmo, Zanette, Simona, Figar, Tiziana Angelica, Angelini, Micol, Pisoni, Camilla, Pitrolo, Antonino Maria Guglielmo, Paolucci, Stefania, Rovida, Francesca, Pellicioli, Isabella, Bonanomi, Ezio, Baldanti, Fausto, Ghirardello, Stefano
Format:	Artikel
Sprache:	eng
Schlagworte:	Babies Echovirus Infections - diagnosis Echovirus Infections - epidemiology Enterovirus B, Human - genetics France - epidemiology Hepatitis Hepatitis A Humans Infant, Newborn Italy - epidemiology Male Massive Hepatic Necrosis Rapid Communication Twins Viruses
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Zusammenfassung:	Echovirus 11 (E11) has recently been associated with a series of nine neonatal cases of severe hepatitis in France. Here, we present severe hepatitis caused by E11 in a pair of twins. In one of the neonates, the clinical picture evolved to fulminant hepatitis. The E11 genome showed 99% nucleotide identity with E11 strains reported in the cases in France. Rapid genome characterisation using next generation sequencing is essential to identify new and more pathogenetic variants.
ISSN:	1560-7917 1025-496X 1560-7917
DOI:	10.2807/1560-7917.ES.2023.28.24.2300289