Leukocyte and platelet rich fibrin in the management of medication-related osteonecrosis of the jaw: A systematic review and meta-analysis

Osteonecrosis of the jaw (ONJ) has a frequent adverse effect after the administration of nitrogenous bisphosphonates, as non-nitrogenous bisphosphonates are metabolized more rapidly and would produce this effect to a lesser extent. The objective of this study is to analyze the results obtained in th...

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Veröffentlicht in:	Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2023-07, Vol.28 (4), p.e317-e329
Hauptverfasser:	Muñoz-Salgado, A, Silva, F-F, Padín-Iruegas, M-E, Camolesi, G-C, Bernaola-Paredes, W-E, Veronese, H-R, Celestino, M-D, Filho, W-J, Lorenzo-Pouso, A-I, Pérez-Sayáns, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Bisphosphonate-Associated Osteonecrosis of the Jaw - therapy Bone Density Conservation Agents - adverse effects Diphosphonates - adverse effects Humans Osteonecrosis - chemically induced Platelet-Rich Fibrin Reproducibility of Results Review
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Zusammenfassung:	Osteonecrosis of the jaw (ONJ) has a frequent adverse effect after the administration of nitrogenous bisphosphonates, as non-nitrogenous bisphosphonates are metabolized more rapidly and would produce this effect to a lesser extent. The objective of this study is to analyze the results obtained in the literature with the use of L-PRF in the treatment of ONJ through a systematic review and meta-analysis. Medline (via PubMed), Cochrane, Web of Science and Grey Literature Database was screened from which 10 were selected. In the meta-analysis with full resolution, combining the use of L-PRF in the treatment of ONJ, a weighted proportion (PP) of 94.3% of complete resolution is obtained (95% CI: 91.2-97.4, p
ISSN:	1698-6946 1698-4447 1698-6946
DOI:	10.4317/medoral.25733