A Reduced Pancreatic Polypeptide Response is Associated With New-onset Pancreatogenic Diabetes Versus Type 2 Diabetes

Abstract Purpose Pancreatogenic diabetes refers to diabetes mellitus (DM) that develops in the setting of a disease of the exocrine pancreas, including pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). We sought to evaluate whether a blunted nutrient response of pancreatic polyp...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2023-05, Vol.108 (5), p.e120-e128
Hauptverfasser:	Hart, Phil A, Kudva, Yogish C, Yadav, Dhiraj, Andersen, Dana K, Li, Yisheng, Toledo, Frederico G S, Wang, Fuchenchu, Bellin, Melena D, Bradley, David, Brand, Randall E, Cusi, Kenneth, Fisher, William, Mather, Kieren, Park, Walter G, Saeed, Zeb, Considine, Robert V, Graham, Sarah C, Rinaudo, Jo Ann, Serrano, Jose, Goodarzi, Mark O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Body mass index Carcinoma, Pancreatic Ductal - complications Clinical Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 Fasting Humans Pancreatic cancer Pancreatic diseases Pancreatic Neoplasms Pancreatic Neoplasms - complications Pancreatic Polypeptide Pancreatitis Pancreatitis, Chronic - complications Polypeptides
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Zusammenfassung:	Abstract Purpose Pancreatogenic diabetes refers to diabetes mellitus (DM) that develops in the setting of a disease of the exocrine pancreas, including pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). We sought to evaluate whether a blunted nutrient response of pancreatic polypeptide (PP) can differentiate these DM subtypes from type 2 DM (T2DM). Methods Subjects with new-onset DM (
ISSN:	0021-972X 1945-7197
DOI:	10.1210/clinem/dgac670