Paraneoplastic Neuromyelitis Optica Spectrum Disorder Related to Glucose-regulated Protein 78 (GRP78) Autoantibodies in a Patient with Lynch Syndrome-associated Colorectal Cancer
Neuromyelitis optica spectrum disorders have been previously reported in a paraneoplastic context, although there is no clear consensus on their pathogenesis. We herein report a case of aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder in a 64-year-old woman with colorectal cancer...
Gespeichert in:
| Veröffentlicht in: | Internal Medicine 2023/06/01, Vol.62(11), pp.1653-1657 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1657 |
|---|---|
| container_issue | 11 |
| container_start_page | 1653 |
| container_title | Internal Medicine |
| container_volume | 62 |
| creator | Minomo, Shogo Ichijo, Masahiko Shimizu, Fumitaka Sato, Ryota Kanda, Takashi Takai, Yoshiki Misu, Tatsuro Sakurai, Yoshiki Amino, Takeshi Kamata, Tomoyuki |
| description | Neuromyelitis optica spectrum disorders have been previously reported in a paraneoplastic context, although there is no clear consensus on their pathogenesis. We herein report a case of aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder in a 64-year-old woman with colorectal cancer. She underwent tumor resection, resulting in serum aquaporin-4 antibody titers subsequently becoming negative. Serum samples were also positive for glucose-regulated protein 78 antibody, which has recently been suggested to be a novel factor in the disruption of the blood-brain barrier. Serological and pathological investigations in this case highlight the role and involvement of aquaporin-4 and glucose-regulated protein 78 antibodies in paraneoplastic conditions. |
| doi_str_mv | 10.2169/internalmedicine.9783-22 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10292989</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2825699156</sourcerecordid><originalsourceid>FETCH-LOGICAL-c556t-90a4070edf2b849f94175497a956d56084839fffc12bbbf8252ccd41fd620dc63</originalsourceid><addsrcrecordid>eNplks9uEzEQxlcIREPhFZAlLuWwxfb-s0-oCiUgRSRq4Wx5vbOJI68dbC8or9UnxEtCBOUylmZ-_mY8_rIMEXxNSc3faRvBW2kG6LTSFq55w4qc0ifZjBQlzxtaVE-zGeaE5TSFi-xFCDuMC9Zw-jy7KGrKGOd0lj2spZcW3N7IELVCX2D0bjiA0VEHtNqnnET3e1DRjwP6oIPzHXh0B0ZG6FB0aGFG5QLkHjbjMbn2LoK2qGHoanG3bthbdDNGJ23Ures0BJSKEq1l1GAj-qnjFi0PVm3R_cF2qT3kMgSn9G-1uTPOp_7SoLm0CvzL7FkvTYBXp_My-_bx9uv8U75cLT7Pb5a5qqo65hzLEjcYup62rOQ9L0lTlbyRvKq7qsasZAXv-14R2rZtz2hFlepK0nc1xZ2qi8vs_VF3P7Zp0SrN6qURe68H6Q_CSS3-rVi9FRv3QxBMOeWMJ4Wrk4J330cIUQw6KDBm2vgYBG0oryjhDU7om0fozo3TFycqjVZzTqppJHaklHcheOjP0xAsJmeIx84QkzMEpenq679fc774xwoJWB2BXYhyA2dA-uQBA_8r11QQMsVTizOpttILsMUvMtjbbg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2825699156</pqid></control><display><type>article</type><title>Paraneoplastic Neuromyelitis Optica Spectrum Disorder Related to Glucose-regulated Protein 78 (GRP78) Autoantibodies in a Patient with Lynch Syndrome-associated Colorectal Cancer</title><source>J-STAGE Free</source><source>MEDLINE</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Minomo, Shogo ; Ichijo, Masahiko ; Shimizu, Fumitaka ; Sato, Ryota ; Kanda, Takashi ; Takai, Yoshiki ; Misu, Tatsuro ; Sakurai, Yoshiki ; Amino, Takeshi ; Kamata, Tomoyuki</creator><creatorcontrib>Minomo, Shogo ; Ichijo, Masahiko ; Shimizu, Fumitaka ; Sato, Ryota ; Kanda, Takashi ; Takai, Yoshiki ; Misu, Tatsuro ; Sakurai, Yoshiki ; Amino, Takeshi ; Kamata, Tomoyuki</creatorcontrib><description>Neuromyelitis optica spectrum disorders have been previously reported in a paraneoplastic context, although there is no clear consensus on their pathogenesis. We herein report a case of aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder in a 64-year-old woman with colorectal cancer. She underwent tumor resection, resulting in serum aquaporin-4 antibody titers subsequently becoming negative. Serum samples were also positive for glucose-regulated protein 78 antibody, which has recently been suggested to be a novel factor in the disruption of the blood-brain barrier. Serological and pathological investigations in this case highlight the role and involvement of aquaporin-4 and glucose-regulated protein 78 antibodies in paraneoplastic conditions.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.9783-22</identifier><identifier>PMID: 36288992</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>AQP4 ; Aquaporin 4 ; Autoantibodies ; Blood-brain barrier ; Case Report ; Case reports ; colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms, Hereditary Nonpolyposis - complications ; Endoplasmic Reticulum Chaperone BiP ; Female ; Glucose ; GRP78 ; Humans ; Internal medicine ; Lynch syndrome ; Middle Aged ; Neuromyelitis ; Neuromyelitis Optica ; paraneoplastic syndrome</subject><ispartof>Internal Medicine, 2023/06/01, Vol.62(11), pp.1653-1657</ispartof><rights>2023 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><rights>Copyright © 2023 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c556t-90a4070edf2b849f94175497a956d56084839fffc12bbbf8252ccd41fd620dc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292989/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292989/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36288992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Minomo, Shogo</creatorcontrib><creatorcontrib>Ichijo, Masahiko</creatorcontrib><creatorcontrib>Shimizu, Fumitaka</creatorcontrib><creatorcontrib>Sato, Ryota</creatorcontrib><creatorcontrib>Kanda, Takashi</creatorcontrib><creatorcontrib>Takai, Yoshiki</creatorcontrib><creatorcontrib>Misu, Tatsuro</creatorcontrib><creatorcontrib>Sakurai, Yoshiki</creatorcontrib><creatorcontrib>Amino, Takeshi</creatorcontrib><creatorcontrib>Kamata, Tomoyuki</creatorcontrib><title>Paraneoplastic Neuromyelitis Optica Spectrum Disorder Related to Glucose-regulated Protein 78 (GRP78) Autoantibodies in a Patient with Lynch Syndrome-associated Colorectal Cancer</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Neuromyelitis optica spectrum disorders have been previously reported in a paraneoplastic context, although there is no clear consensus on their pathogenesis. We herein report a case of aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder in a 64-year-old woman with colorectal cancer. She underwent tumor resection, resulting in serum aquaporin-4 antibody titers subsequently becoming negative. Serum samples were also positive for glucose-regulated protein 78 antibody, which has recently been suggested to be a novel factor in the disruption of the blood-brain barrier. Serological and pathological investigations in this case highlight the role and involvement of aquaporin-4 and glucose-regulated protein 78 antibodies in paraneoplastic conditions.</description><subject>AQP4</subject><subject>Aquaporin 4</subject><subject>Autoantibodies</subject><subject>Blood-brain barrier</subject><subject>Case Report</subject><subject>Case reports</subject><subject>colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms, Hereditary Nonpolyposis - complications</subject><subject>Endoplasmic Reticulum Chaperone BiP</subject><subject>Female</subject><subject>Glucose</subject><subject>GRP78</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Lynch syndrome</subject><subject>Middle Aged</subject><subject>Neuromyelitis</subject><subject>Neuromyelitis Optica</subject><subject>paraneoplastic syndrome</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplks9uEzEQxlcIREPhFZAlLuWwxfb-s0-oCiUgRSRq4Wx5vbOJI68dbC8or9UnxEtCBOUylmZ-_mY8_rIMEXxNSc3faRvBW2kG6LTSFq55w4qc0ifZjBQlzxtaVE-zGeaE5TSFi-xFCDuMC9Zw-jy7KGrKGOd0lj2spZcW3N7IELVCX2D0bjiA0VEHtNqnnET3e1DRjwP6oIPzHXh0B0ZG6FB0aGFG5QLkHjbjMbn2LoK2qGHoanG3bthbdDNGJ23Ures0BJSKEq1l1GAj-qnjFi0PVm3R_cF2qT3kMgSn9G-1uTPOp_7SoLm0CvzL7FkvTYBXp_My-_bx9uv8U75cLT7Pb5a5qqo65hzLEjcYup62rOQ9L0lTlbyRvKq7qsasZAXv-14R2rZtz2hFlepK0nc1xZ2qi8vs_VF3P7Zp0SrN6qURe68H6Q_CSS3-rVi9FRv3QxBMOeWMJ4Wrk4J330cIUQw6KDBm2vgYBG0oryjhDU7om0fozo3TFycqjVZzTqppJHaklHcheOjP0xAsJmeIx84QkzMEpenq679fc774xwoJWB2BXYhyA2dA-uQBA_8r11QQMsVTizOpttILsMUvMtjbbg</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Minomo, Shogo</creator><creator>Ichijo, Masahiko</creator><creator>Shimizu, Fumitaka</creator><creator>Sato, Ryota</creator><creator>Kanda, Takashi</creator><creator>Takai, Yoshiki</creator><creator>Misu, Tatsuro</creator><creator>Sakurai, Yoshiki</creator><creator>Amino, Takeshi</creator><creator>Kamata, Tomoyuki</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230601</creationdate><title>Paraneoplastic Neuromyelitis Optica Spectrum Disorder Related to Glucose-regulated Protein 78 (GRP78) Autoantibodies in a Patient with Lynch Syndrome-associated Colorectal Cancer</title><author>Minomo, Shogo ; Ichijo, Masahiko ; Shimizu, Fumitaka ; Sato, Ryota ; Kanda, Takashi ; Takai, Yoshiki ; Misu, Tatsuro ; Sakurai, Yoshiki ; Amino, Takeshi ; Kamata, Tomoyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-90a4070edf2b849f94175497a956d56084839fffc12bbbf8252ccd41fd620dc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>AQP4</topic><topic>Aquaporin 4</topic><topic>Autoantibodies</topic><topic>Blood-brain barrier</topic><topic>Case Report</topic><topic>Case reports</topic><topic>colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms, Hereditary Nonpolyposis - complications</topic><topic>Endoplasmic Reticulum Chaperone BiP</topic><topic>Female</topic><topic>Glucose</topic><topic>GRP78</topic><topic>Humans</topic><topic>Internal medicine</topic><topic>Lynch syndrome</topic><topic>Middle Aged</topic><topic>Neuromyelitis</topic><topic>Neuromyelitis Optica</topic><topic>paraneoplastic syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Minomo, Shogo</creatorcontrib><creatorcontrib>Ichijo, Masahiko</creatorcontrib><creatorcontrib>Shimizu, Fumitaka</creatorcontrib><creatorcontrib>Sato, Ryota</creatorcontrib><creatorcontrib>Kanda, Takashi</creatorcontrib><creatorcontrib>Takai, Yoshiki</creatorcontrib><creatorcontrib>Misu, Tatsuro</creatorcontrib><creatorcontrib>Sakurai, Yoshiki</creatorcontrib><creatorcontrib>Amino, Takeshi</creatorcontrib><creatorcontrib>Kamata, Tomoyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minomo, Shogo</au><au>Ichijo, Masahiko</au><au>Shimizu, Fumitaka</au><au>Sato, Ryota</au><au>Kanda, Takashi</au><au>Takai, Yoshiki</au><au>Misu, Tatsuro</au><au>Sakurai, Yoshiki</au><au>Amino, Takeshi</au><au>Kamata, Tomoyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paraneoplastic Neuromyelitis Optica Spectrum Disorder Related to Glucose-regulated Protein 78 (GRP78) Autoantibodies in a Patient with Lynch Syndrome-associated Colorectal Cancer</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>62</volume><issue>11</issue><spage>1653</spage><epage>1657</epage><pages>1653-1657</pages><artnum>9783-22</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Neuromyelitis optica spectrum disorders have been previously reported in a paraneoplastic context, although there is no clear consensus on their pathogenesis. We herein report a case of aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder in a 64-year-old woman with colorectal cancer. She underwent tumor resection, resulting in serum aquaporin-4 antibody titers subsequently becoming negative. Serum samples were also positive for glucose-regulated protein 78 antibody, which has recently been suggested to be a novel factor in the disruption of the blood-brain barrier. Serological and pathological investigations in this case highlight the role and involvement of aquaporin-4 and glucose-regulated protein 78 antibodies in paraneoplastic conditions.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>36288992</pmid><doi>10.2169/internalmedicine.9783-22</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-2918 |
| ispartof | Internal Medicine, 2023/06/01, Vol.62(11), pp.1653-1657 |
| issn | 0918-2918 1349-7235 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10292989 |
| source | J-STAGE Free; MEDLINE; PubMed Central; PubMed Central Open Access |
| subjects | AQP4 Aquaporin 4 Autoantibodies Blood-brain barrier Case Report Case reports colorectal cancer Colorectal carcinoma Colorectal Neoplasms, Hereditary Nonpolyposis - complications Endoplasmic Reticulum Chaperone BiP Female Glucose GRP78 Humans Internal medicine Lynch syndrome Middle Aged Neuromyelitis Neuromyelitis Optica paraneoplastic syndrome |
| title | Paraneoplastic Neuromyelitis Optica Spectrum Disorder Related to Glucose-regulated Protein 78 (GRP78) Autoantibodies in a Patient with Lynch Syndrome-associated Colorectal Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T20%3A44%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Paraneoplastic%20Neuromyelitis%20Optica%20Spectrum%20Disorder%20Related%20to%20Glucose-regulated%20Protein%2078%20(GRP78)%20Autoantibodies%20in%20a%20Patient%20with%20Lynch%20Syndrome-associated%20Colorectal%20Cancer&rft.jtitle=Internal%20Medicine&rft.au=Minomo,%20Shogo&rft.date=2023-06-01&rft.volume=62&rft.issue=11&rft.spage=1653&rft.epage=1657&rft.pages=1653-1657&rft.artnum=9783-22&rft.issn=0918-2918&rft.eissn=1349-7235&rft_id=info:doi/10.2169/internalmedicine.9783-22&rft_dat=%3Cproquest_pubme%3E2825699156%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2825699156&rft_id=info:pmid/36288992&rfr_iscdi=true |