Paraneoplastic Neuromyelitis Optica Spectrum Disorder Related to Glucose-regulated Protein 78 (GRP78) Autoantibodies in a Patient with Lynch Syndrome-associated Colorectal Cancer

Neuromyelitis optica spectrum disorders have been previously reported in a paraneoplastic context, although there is no clear consensus on their pathogenesis. We herein report a case of aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder in a 64-year-old woman with colorectal cancer...

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Veröffentlicht in:Internal Medicine 2023/06/01, Vol.62(11), pp.1653-1657
Hauptverfasser: Minomo, Shogo, Ichijo, Masahiko, Shimizu, Fumitaka, Sato, Ryota, Kanda, Takashi, Takai, Yoshiki, Misu, Tatsuro, Sakurai, Yoshiki, Amino, Takeshi, Kamata, Tomoyuki
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Sprache:eng
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Zusammenfassung:Neuromyelitis optica spectrum disorders have been previously reported in a paraneoplastic context, although there is no clear consensus on their pathogenesis. We herein report a case of aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder in a 64-year-old woman with colorectal cancer. She underwent tumor resection, resulting in serum aquaporin-4 antibody titers subsequently becoming negative. Serum samples were also positive for glucose-regulated protein 78 antibody, which has recently been suggested to be a novel factor in the disruption of the blood-brain barrier. Serological and pathological investigations in this case highlight the role and involvement of aquaporin-4 and glucose-regulated protein 78 antibodies in paraneoplastic conditions.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.9783-22