Brain dopamine metabolism in patients with Parkinson's disease measured with positron emission tomography

L-[18F] fluorodopa was administered in trace amounts intravenously to healthy control subjects and to patients with Parkinson's disease. Striatal uptake of radioactivity was measured using positron emission tomography. The capacity of the striatum to retain tracer was severely impaired in patie...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1986-08, Vol.49 (8), p.853-860
Hauptverfasser:	Leenders, K L, Palmer, A J, Quinn, N, Clark, J C, Firnau, G, Garnett, E S, Nahmias, C, Jones, T, Marsden, C D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Brain - metabolism Corpus Striatum - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dihydroxyphenylalanine - analogs & derivatives Dihydroxyphenylalanine - metabolism Dopamine - metabolism Female Humans Levodopa - therapeutic use Male Medical sciences Middle Aged Neurology Parkinson Disease - drug therapy Parkinson Disease - metabolism Tomography, Emission-Computed
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Zusammenfassung:	L-[18F] fluorodopa was administered in trace amounts intravenously to healthy control subjects and to patients with Parkinson's disease. Striatal uptake of radioactivity was measured using positron emission tomography. The capacity of the striatum to retain tracer was severely impaired in patients compared to controls. This may reflect a reduction of striatal dopamine storage in Parkinson's disease. Patients showing the "on/off" phenomenon had an even greater decrease of striatal storage capacity.
ISSN:	0022-3050 1468-330X
DOI:	10.1136/jnnp.49.8.853