Kidney function and renal resistive index in children with juvenile idiopathic arthritis
Juvenile idiopathic arthritis (JIA) is a common pediatric rheumatic disease. Renal manifestations have been rarely observed in JIA, although amyloidosis could be a renal complication in systemic JIA (sJIA). To investigate renal damage in JIA children and to establish the relationship with treatment....
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| Veröffentlicht in: | Clinical and experimental medicine 2023-07, Vol.23 (3), p.759-766 |
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| creator | Cafarotti, Alessandro Marcovecchio, Maria Loredana Lapergola, Giuseppe Di Battista, Caterina Marsili, Manuela Basilico, Raffaella Di Donato, Giulia David, Daniela Pelliccia, Piernicola Chiarelli, Francesco Breda, Luciana |
| description | Juvenile idiopathic arthritis (JIA) is a common pediatric rheumatic disease. Renal manifestations have been rarely observed in JIA, although amyloidosis could be a renal complication in systemic JIA (sJIA). To investigate renal damage in JIA children and to establish the relationship with treatment. Blood urea nitrogen (BUN), creatinine, cystatin C (CysC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), urinary albumin excretion (UAE), estimated glomerular filtration rate (eGFR), and renal resistive index (RRI) were assessed in 49 JIA children (9 boys/40 girls, mean age 10.3 ± 3.8 years) and in 49 healthy controls (24 boys/25 girls, mean age 11.3 ± 3.4 years). Twenty-two JIA patients were on methotrexate (MTX) therapy (group A) and 27 on biologic drugs (group B). CysC and BUN (respectively, 0.8 ± 0.1 vs. 0.7 ± 0.1 mg/dl; 13.3 ± 2.9 vs. 11.7 ± 1.4 mg/dl) were higher (
p
≤ 0.001) whereas creatinine and eGFR (respectively, 0.5 ± 0.1 vs. 0.6 ± 0.1 mg/dl; 99.2 ± 10.5 vs. 122.5 ± 19.8 ml/min/1.73 m
2
) were lower in JIA children as compared to controls (
p
|
| doi_str_mv | 10.1007/s10238-022-00898-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10284920</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2828399568</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-49cd6a49f696de942d7a808ed49a938c659b1f14159485b3467e10ffc1a3fec43</originalsourceid><addsrcrecordid>eNp9kU9PFTEUxRsjEUS_AAsziRs3A_0_7YoQImokcQOJu6avvcP0ZV7n2XYej29P8SGgCze3Tc7vnvbeg9ARwccE4-4kE0yZajGlLcZKq3b7Ch0QoUmrBVWvX9z30duclxgToRh-g_aZJFQLoQ7Qz-_BR7hr-jm6EqbY2OibBNGOteaQS9hAE6KHba2NG8Loq9rchjI0y3kDMYxV92Fa2zIE19hUhhRKyO_QXm_HDO8fz0N0ffH56vxre_njy7fzs8vW8U6UlmvnpeW6l1p60Jz6ziqswHNtNVNOCr0gPeF1FK7EgnHZAcF974hlPTjODtHpznc9L1bgHcSS7GjWKaxsujOTDeZvJYbB3EwbU5enuKa4Onx6dEjTrxlyMauQHYyjjTDN2dCOSEGlpLqiH_9Bl9Oc6rIqpahiWgupKkV3lEtTzgn6p98QbB6SM7vkTE3O_E7ObGvTh5dzPLX8iaoCbAfkKsUbSM9v_8f2HrWzpkc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2828399568</pqid></control><display><type>article</type><title>Kidney function and renal resistive index in children with juvenile idiopathic arthritis</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Cafarotti, Alessandro ; Marcovecchio, Maria Loredana ; Lapergola, Giuseppe ; Di Battista, Caterina ; Marsili, Manuela ; Basilico, Raffaella ; Di Donato, Giulia ; David, Daniela ; Pelliccia, Piernicola ; Chiarelli, Francesco ; Breda, Luciana</creator><creatorcontrib>Cafarotti, Alessandro ; Marcovecchio, Maria Loredana ; Lapergola, Giuseppe ; Di Battista, Caterina ; Marsili, Manuela ; Basilico, Raffaella ; Di Donato, Giulia ; David, Daniela ; Pelliccia, Piernicola ; Chiarelli, Francesco ; Breda, Luciana</creatorcontrib><description>Juvenile idiopathic arthritis (JIA) is a common pediatric rheumatic disease. Renal manifestations have been rarely observed in JIA, although amyloidosis could be a renal complication in systemic JIA (sJIA). To investigate renal damage in JIA children and to establish the relationship with treatment. Blood urea nitrogen (BUN), creatinine, cystatin C (CysC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), urinary albumin excretion (UAE), estimated glomerular filtration rate (eGFR), and renal resistive index (RRI) were assessed in 49 JIA children (9 boys/40 girls, mean age 10.3 ± 3.8 years) and in 49 healthy controls (24 boys/25 girls, mean age 11.3 ± 3.4 years). Twenty-two JIA patients were on methotrexate (MTX) therapy (group A) and 27 on biologic drugs (group B). CysC and BUN (respectively, 0.8 ± 0.1 vs. 0.7 ± 0.1 mg/dl; 13.3 ± 2.9 vs. 11.7 ± 1.4 mg/dl) were higher (
p
≤ 0.001) whereas creatinine and eGFR (respectively, 0.5 ± 0.1 vs. 0.6 ± 0.1 mg/dl; 99.2 ± 10.5 vs. 122.5 ± 19.8 ml/min/1.73 m
2
) were lower in JIA children as compared to controls (
p
< 0.001). UAE resulted higher in patients than in controls (
p
= 0.003). Mean RRI was higher in JIA children than controls (0.7 ± 0.04 vs. 0.6 ± 0.04;
p
< 0.001). Group B showed higher mean RRI than group A (0.7 ± 0.1 vs. 0.7 ± 0.04;
p
< 0.001). Associations were found between RRI and ESR, JADAS-27, disease state, BMI-SDS (
p
< 0.001), CRP (
p
= 0.003) and eGFR (
p
= 0.001). JIA children had reduced eGFR, increased UAE and higher RRI values, than controls. RRIs were higher in patients on biologic drugs than MTX group and were associated with inflammation indexes and disease state, suggesting a direct effect of the disease.</description><identifier>ISSN: 1591-9528</identifier><identifier>ISSN: 1591-8890</identifier><identifier>EISSN: 1591-9528</identifier><identifier>DOI: 10.1007/s10238-022-00898-x</identifier><identifier>PMID: 36129558</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adolescent ; Amyloidosis ; Arthritis ; Arthritis, Juvenile - complications ; Arthritis, Juvenile - drug therapy ; C-reactive protein ; Child ; Children ; Clinical Practice ; Creatinine ; Cystatin C ; Epidermal growth factor receptors ; Erythrocyte sedimentation rate ; Female ; Glomerular filtration rate ; Hematology ; Humans ; Inflammation - complications ; Internal Medicine ; Kidney ; Male ; Medicine ; Medicine & Public Health ; Methotrexate ; Methotrexate - therapeutic use ; Oncology ; Patients ; Pediatrics ; Renal function ; Review ; Review Article</subject><ispartof>Clinical and experimental medicine, 2023-07, Vol.23 (3), p.759-766</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-49cd6a49f696de942d7a808ed49a938c659b1f14159485b3467e10ffc1a3fec43</citedby><cites>FETCH-LOGICAL-c475t-49cd6a49f696de942d7a808ed49a938c659b1f14159485b3467e10ffc1a3fec43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10238-022-00898-x$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10238-022-00898-x$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36129558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cafarotti, Alessandro</creatorcontrib><creatorcontrib>Marcovecchio, Maria Loredana</creatorcontrib><creatorcontrib>Lapergola, Giuseppe</creatorcontrib><creatorcontrib>Di Battista, Caterina</creatorcontrib><creatorcontrib>Marsili, Manuela</creatorcontrib><creatorcontrib>Basilico, Raffaella</creatorcontrib><creatorcontrib>Di Donato, Giulia</creatorcontrib><creatorcontrib>David, Daniela</creatorcontrib><creatorcontrib>Pelliccia, Piernicola</creatorcontrib><creatorcontrib>Chiarelli, Francesco</creatorcontrib><creatorcontrib>Breda, Luciana</creatorcontrib><title>Kidney function and renal resistive index in children with juvenile idiopathic arthritis</title><title>Clinical and experimental medicine</title><addtitle>Clin Exp Med</addtitle><addtitle>Clin Exp Med</addtitle><description>Juvenile idiopathic arthritis (JIA) is a common pediatric rheumatic disease. Renal manifestations have been rarely observed in JIA, although amyloidosis could be a renal complication in systemic JIA (sJIA). To investigate renal damage in JIA children and to establish the relationship with treatment. Blood urea nitrogen (BUN), creatinine, cystatin C (CysC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), urinary albumin excretion (UAE), estimated glomerular filtration rate (eGFR), and renal resistive index (RRI) were assessed in 49 JIA children (9 boys/40 girls, mean age 10.3 ± 3.8 years) and in 49 healthy controls (24 boys/25 girls, mean age 11.3 ± 3.4 years). Twenty-two JIA patients were on methotrexate (MTX) therapy (group A) and 27 on biologic drugs (group B). CysC and BUN (respectively, 0.8 ± 0.1 vs. 0.7 ± 0.1 mg/dl; 13.3 ± 2.9 vs. 11.7 ± 1.4 mg/dl) were higher (
p
≤ 0.001) whereas creatinine and eGFR (respectively, 0.5 ± 0.1 vs. 0.6 ± 0.1 mg/dl; 99.2 ± 10.5 vs. 122.5 ± 19.8 ml/min/1.73 m
2
) were lower in JIA children as compared to controls (
p
< 0.001). UAE resulted higher in patients than in controls (
p
= 0.003). Mean RRI was higher in JIA children than controls (0.7 ± 0.04 vs. 0.6 ± 0.04;
p
< 0.001). Group B showed higher mean RRI than group A (0.7 ± 0.1 vs. 0.7 ± 0.04;
p
< 0.001). Associations were found between RRI and ESR, JADAS-27, disease state, BMI-SDS (
p
< 0.001), CRP (
p
= 0.003) and eGFR (
p
= 0.001). JIA children had reduced eGFR, increased UAE and higher RRI values, than controls. RRIs were higher in patients on biologic drugs than MTX group and were associated with inflammation indexes and disease state, suggesting a direct effect of the disease.</description><subject>Adolescent</subject><subject>Amyloidosis</subject><subject>Arthritis</subject><subject>Arthritis, Juvenile - complications</subject><subject>Arthritis, Juvenile - drug therapy</subject><subject>C-reactive protein</subject><subject>Child</subject><subject>Children</subject><subject>Clinical Practice</subject><subject>Creatinine</subject><subject>Cystatin C</subject><subject>Epidermal growth factor receptors</subject><subject>Erythrocyte sedimentation rate</subject><subject>Female</subject><subject>Glomerular filtration rate</subject><subject>Hematology</subject><subject>Humans</subject><subject>Inflammation - complications</subject><subject>Internal Medicine</subject><subject>Kidney</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methotrexate</subject><subject>Methotrexate - therapeutic use</subject><subject>Oncology</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Renal function</subject><subject>Review</subject><subject>Review Article</subject><issn>1591-9528</issn><issn>1591-8890</issn><issn>1591-9528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU9PFTEUxRsjEUS_AAsziRs3A_0_7YoQImokcQOJu6avvcP0ZV7n2XYej29P8SGgCze3Tc7vnvbeg9ARwccE4-4kE0yZajGlLcZKq3b7Ch0QoUmrBVWvX9z30duclxgToRh-g_aZJFQLoQ7Qz-_BR7hr-jm6EqbY2OibBNGOteaQS9hAE6KHba2NG8Loq9rchjI0y3kDMYxV92Fa2zIE19hUhhRKyO_QXm_HDO8fz0N0ffH56vxre_njy7fzs8vW8U6UlmvnpeW6l1p60Jz6ziqswHNtNVNOCr0gPeF1FK7EgnHZAcF974hlPTjODtHpznc9L1bgHcSS7GjWKaxsujOTDeZvJYbB3EwbU5enuKa4Onx6dEjTrxlyMauQHYyjjTDN2dCOSEGlpLqiH_9Bl9Oc6rIqpahiWgupKkV3lEtTzgn6p98QbB6SM7vkTE3O_E7ObGvTh5dzPLX8iaoCbAfkKsUbSM9v_8f2HrWzpkc</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Cafarotti, Alessandro</creator><creator>Marcovecchio, Maria Loredana</creator><creator>Lapergola, Giuseppe</creator><creator>Di Battista, Caterina</creator><creator>Marsili, Manuela</creator><creator>Basilico, Raffaella</creator><creator>Di Donato, Giulia</creator><creator>David, Daniela</creator><creator>Pelliccia, Piernicola</creator><creator>Chiarelli, Francesco</creator><creator>Breda, Luciana</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230701</creationdate><title>Kidney function and renal resistive index in children with juvenile idiopathic arthritis</title><author>Cafarotti, Alessandro ; Marcovecchio, Maria Loredana ; Lapergola, Giuseppe ; Di Battista, Caterina ; Marsili, Manuela ; Basilico, Raffaella ; Di Donato, Giulia ; David, Daniela ; Pelliccia, Piernicola ; Chiarelli, Francesco ; Breda, Luciana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-49cd6a49f696de942d7a808ed49a938c659b1f14159485b3467e10ffc1a3fec43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescent</topic><topic>Amyloidosis</topic><topic>Arthritis</topic><topic>Arthritis, Juvenile - complications</topic><topic>Arthritis, Juvenile - drug therapy</topic><topic>C-reactive protein</topic><topic>Child</topic><topic>Children</topic><topic>Clinical Practice</topic><topic>Creatinine</topic><topic>Cystatin C</topic><topic>Epidermal growth factor receptors</topic><topic>Erythrocyte sedimentation rate</topic><topic>Female</topic><topic>Glomerular filtration rate</topic><topic>Hematology</topic><topic>Humans</topic><topic>Inflammation - complications</topic><topic>Internal Medicine</topic><topic>Kidney</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methotrexate</topic><topic>Methotrexate - therapeutic use</topic><topic>Oncology</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Renal function</topic><topic>Review</topic><topic>Review Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cafarotti, Alessandro</creatorcontrib><creatorcontrib>Marcovecchio, Maria Loredana</creatorcontrib><creatorcontrib>Lapergola, Giuseppe</creatorcontrib><creatorcontrib>Di Battista, Caterina</creatorcontrib><creatorcontrib>Marsili, Manuela</creatorcontrib><creatorcontrib>Basilico, Raffaella</creatorcontrib><creatorcontrib>Di Donato, Giulia</creatorcontrib><creatorcontrib>David, Daniela</creatorcontrib><creatorcontrib>Pelliccia, Piernicola</creatorcontrib><creatorcontrib>Chiarelli, Francesco</creatorcontrib><creatorcontrib>Breda, Luciana</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cafarotti, Alessandro</au><au>Marcovecchio, Maria Loredana</au><au>Lapergola, Giuseppe</au><au>Di Battista, Caterina</au><au>Marsili, Manuela</au><au>Basilico, Raffaella</au><au>Di Donato, Giulia</au><au>David, Daniela</au><au>Pelliccia, Piernicola</au><au>Chiarelli, Francesco</au><au>Breda, Luciana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kidney function and renal resistive index in children with juvenile idiopathic arthritis</atitle><jtitle>Clinical and experimental medicine</jtitle><stitle>Clin Exp Med</stitle><addtitle>Clin Exp Med</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>23</volume><issue>3</issue><spage>759</spage><epage>766</epage><pages>759-766</pages><issn>1591-9528</issn><issn>1591-8890</issn><eissn>1591-9528</eissn><abstract>Juvenile idiopathic arthritis (JIA) is a common pediatric rheumatic disease. Renal manifestations have been rarely observed in JIA, although amyloidosis could be a renal complication in systemic JIA (sJIA). To investigate renal damage in JIA children and to establish the relationship with treatment. Blood urea nitrogen (BUN), creatinine, cystatin C (CysC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), urinary albumin excretion (UAE), estimated glomerular filtration rate (eGFR), and renal resistive index (RRI) were assessed in 49 JIA children (9 boys/40 girls, mean age 10.3 ± 3.8 years) and in 49 healthy controls (24 boys/25 girls, mean age 11.3 ± 3.4 years). Twenty-two JIA patients were on methotrexate (MTX) therapy (group A) and 27 on biologic drugs (group B). CysC and BUN (respectively, 0.8 ± 0.1 vs. 0.7 ± 0.1 mg/dl; 13.3 ± 2.9 vs. 11.7 ± 1.4 mg/dl) were higher (
p
≤ 0.001) whereas creatinine and eGFR (respectively, 0.5 ± 0.1 vs. 0.6 ± 0.1 mg/dl; 99.2 ± 10.5 vs. 122.5 ± 19.8 ml/min/1.73 m
2
) were lower in JIA children as compared to controls (
p
< 0.001). UAE resulted higher in patients than in controls (
p
= 0.003). Mean RRI was higher in JIA children than controls (0.7 ± 0.04 vs. 0.6 ± 0.04;
p
< 0.001). Group B showed higher mean RRI than group A (0.7 ± 0.1 vs. 0.7 ± 0.04;
p
< 0.001). Associations were found between RRI and ESR, JADAS-27, disease state, BMI-SDS (
p
< 0.001), CRP (
p
= 0.003) and eGFR (
p
= 0.001). JIA children had reduced eGFR, increased UAE and higher RRI values, than controls. RRIs were higher in patients on biologic drugs than MTX group and were associated with inflammation indexes and disease state, suggesting a direct effect of the disease.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36129558</pmid><doi>10.1007/s10238-022-00898-x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Amyloidosis Arthritis Arthritis, Juvenile - complications Arthritis, Juvenile - drug therapy C-reactive protein Child Children Clinical Practice Creatinine Cystatin C Epidermal growth factor receptors Erythrocyte sedimentation rate Female Glomerular filtration rate Hematology Humans Inflammation - complications Internal Medicine Kidney Male Medicine Medicine & Public Health Methotrexate Methotrexate - therapeutic use Oncology Patients Pediatrics Renal function Review Review Article |
| title | Kidney function and renal resistive index in children with juvenile idiopathic arthritis |
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