Kidney function and renal resistive index in children with juvenile idiopathic arthritis

Juvenile idiopathic arthritis (JIA) is a common pediatric rheumatic disease. Renal manifestations have been rarely observed in JIA, although amyloidosis could be a renal complication in systemic JIA (sJIA). To investigate renal damage in JIA children and to establish the relationship with treatment....

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Veröffentlicht in:Clinical and experimental medicine 2023-07, Vol.23 (3), p.759-766
Hauptverfasser: Cafarotti, Alessandro, Marcovecchio, Maria Loredana, Lapergola, Giuseppe, Di Battista, Caterina, Marsili, Manuela, Basilico, Raffaella, Di Donato, Giulia, David, Daniela, Pelliccia, Piernicola, Chiarelli, Francesco, Breda, Luciana
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Sprache:eng
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Zusammenfassung:Juvenile idiopathic arthritis (JIA) is a common pediatric rheumatic disease. Renal manifestations have been rarely observed in JIA, although amyloidosis could be a renal complication in systemic JIA (sJIA). To investigate renal damage in JIA children and to establish the relationship with treatment. Blood urea nitrogen (BUN), creatinine, cystatin C (CysC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), urinary albumin excretion (UAE), estimated glomerular filtration rate (eGFR), and renal resistive index (RRI) were assessed in 49 JIA children (9 boys/40 girls, mean age 10.3 ± 3.8 years) and in 49 healthy controls (24 boys/25 girls, mean age 11.3 ± 3.4 years). Twenty-two JIA patients were on methotrexate (MTX) therapy (group A) and 27 on biologic drugs (group B). CysC and BUN (respectively, 0.8 ± 0.1 vs. 0.7 ± 0.1 mg/dl; 13.3 ± 2.9 vs. 11.7 ± 1.4 mg/dl) were higher ( p  ≤ 0.001) whereas creatinine and eGFR (respectively, 0.5 ± 0.1 vs. 0.6 ± 0.1 mg/dl; 99.2 ± 10.5 vs. 122.5 ± 19.8 ml/min/1.73 m 2 ) were lower in JIA children as compared to controls ( p  
ISSN:1591-9528
1591-8890
1591-9528
DOI:10.1007/s10238-022-00898-x