Effect of neuroleptic treatment on involuntary movements and motor performances in Huntington's disease

Eighteen patients with Huntington's chorea were examined before and after neuroleptic treatment (haloperidol, pimozide, tiapride) to study the effect of such treatment on hyperkinesia and motor performance. Pimozide and haloperidol improved hyperkinesia; none of the drugs significantly affected...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1984-08, Vol.47 (8), p.848-852
Hauptverfasser:	Girotti, F, Carella, F, Scigliano, G, Grassi, M P, Soliveri, P, Giovannini, P, Parati, E, Caraceni, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antipsychotic Agents - therapeutic use Biological and medical sciences Female Haloperidol - therapeutic use Humans Huntington Disease - drug therapy Male Medical sciences Middle Aged Motor Activity - drug effects Motor Skills - drug effects Neuropharmacology Pharmacology. Drug treatments Pimozide - therapeutic use Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - drug effects Psychopharmacology Tiapamil Hydrochloride - therapeutic use
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Zusammenfassung:	Eighteen patients with Huntington's chorea were examined before and after neuroleptic treatment (haloperidol, pimozide, tiapride) to study the effect of such treatment on hyperkinesia and motor performance. Pimozide and haloperidol improved hyperkinesia; none of the drugs significantly affected motor performance. No correlation was found between the severity of hyperkinesia and motor performance scores, or between hyperkinesia and intelligence score, before and after therapy.
ISSN:	0022-3050 1468-330X
DOI:	10.1136/jnnp.47.8.848