Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts

Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts

Previous studies have hypothesized that autozygosity is decreasing over generational time. However, these studies were limited to relatively small samples (n 

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Bibliographische Detailangaben
Veröffentlicht in:American journal of human genetics 2023-06, Vol.110 (6), p.1008-1014
Hauptverfasser: Colbert, Sarah M.C., Wendt, Frank R., Pathak, Gita A., Helmer, Drew A., Hauser, Elizabeth R., Keller, Matthew C., Polimanti, Renato, Johnson, Emma C.
Format: Artikel
Sprache:eng
Schlagworte:
autozygosity
FROH
Homozygote
Humans
panmixia
Polymorphism, Single Nucleotide
Population Health
runs of homozygosity
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Beschreibung
Zusammenfassung:Previous studies have hypothesized that autozygosity is decreasing over generational time. However, these studies were limited to relatively small samples (n 
ISSN:0002-9297
1537-6605
1537-6605
DOI:10.1016/j.ajhg.2023.04.007