Upregulation of MAPKAPK5‐AS1, PXN‐AS1 and URB1‐AS1 lncRNAs in non‐functioning pituitary adenoma

Long non‐coding RNAs (lncRNAs) have been shown to be dysregulated in a variety of malignant and non‐malignant lesions including non‐functioning pituitary adenomas (NFPAs). In the current experimental study, we have selected six lncRNAs, namely MAPKAPK5‐AS1, NUTM2B‐AS1, ST7‐AS1, LIFR‐AS1, PXN‐AS1 and...

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Veröffentlicht in:Journal of cellular and molecular medicine 2023-06, Vol.27 (11), p.1550-1556
Hauptverfasser: Taheri, Mohammad, Safarzadeh, Arash, Bahranian, Arefe, Eslami, Solat, Dilmaghani, Nader Akbari, Ghafouri‐Fard, Soudeh, Sharifi, Guive
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Sprache:eng
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Zusammenfassung:Long non‐coding RNAs (lncRNAs) have been shown to be dysregulated in a variety of malignant and non‐malignant lesions including non‐functioning pituitary adenomas (NFPAs). In the current experimental study, we have selected six lncRNAs, namely MAPKAPK5‐AS1, NUTM2B‐AS1, ST7‐AS1, LIFR‐AS1, PXN‐AS1 and URB1‐AS1 to assess their expression in a cohort of Iranian patients with NFPA. MAPKAPK5‐AS1, PXN‐AS1 and URB1‐AS1 were shown to be over‐expressed in NFPA tissues compared with control samples (Expression ratios (95% CI) = 10 (3.94–25.36), 11.22 (4.3–28.8) and 9.33 (4.12–21.12); p values 
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.17763