Expression profiles and potential roles of serum tRNA‑derived fragments in diabetic nephropathy

Diabetic nephropathy (DN) is one of the most important causes of end-stage renal disease and current treatments are ineffective in preventing its progression. Transfer RNA (tRNA)-derived fragments (tRFs), which are small non-coding fragments derived from tRNA precursors or mature tRNAs, have a criti...

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Veröffentlicht in:Experimental and therapeutic medicine 2023-07, Vol.26 (1), p.311, Article 311
Hauptverfasser: Huang, Chan, Ding, Ling, Ji, Jialing, Qiao, Yunyang, Xia, Zihuan, Shi, Huimin, Zhang, Shiting, Gan, Weihua, Zhang, Aiqing
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Sprache:eng
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Zusammenfassung:Diabetic nephropathy (DN) is one of the most important causes of end-stage renal disease and current treatments are ineffective in preventing its progression. Transfer RNA (tRNA)-derived fragments (tRFs), which are small non-coding fragments derived from tRNA precursors or mature tRNAs, have a critical role in various human diseases. The present study aimed to investigate the expression profile and potential functions of tRFs in DN. High-throughput sequencing technology was employed to detect the differential serum levels of tRFs between DN and diabetes mellitus and to validate the reliability of the sequencing results using reverse transcription-quantitative PCR. Ultimately, six differentially expressed (DE) tRFs were identified (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2023.12010