Apolipoprotein C1 promotes tumor progression in gastric cancer

Gastric cancer (GC) is a malignancy with the worst prognosis that seriously threatens human health, especially in East Asia. Apolipoprotein C1 ( ) belongs to the apolipoprotein family. In addition, has been associated with various tumors. However, its role in GC remains unclear. Firstly, we quantified its expression in GC and adjacent tumor tissues, using The Cancer Genome Atlas (TCGA). Next, we assessed cell invasion and migration abilities. Finally, we revealed the role of in the tumor microenvironment (TME), immune cell infiltration and drug sensitivity. Firstly, in TCGA database, it has been shown that elevated expression of was identified in various cancers, including GC, then we found that high expression of was significantly correlated with poor prognosis in GC. Histologically, expression is proportional to grade, cancer stage, and T stage. The experimental results showed that promoted cell invasion and migration. Then GO, KEGG, and GSEA pathway analyses indicated that may be involved in the WNT pathway and immune regulation. Furthermore, we found out the tumor-infiltrating immune cells related to in the tumor microenvironment (TME) using TIMER. Finally, we investigated the correlation between expression and drug sensitivity, PD-1 and CTLA-4 therapy. These results suggest that participates in the evolution of GC, and may represent a potential target for detection and immunotherapy in GC.