Coordinated Reset Deep Brain Stimulation of Subthalamic Nucleus Produces Long-Lasting, Dose-Dependent Motor Improvements in the 1- Methyl -4- Phenyl -1,2,3,6-Tetrahydropyridine Non-Human Primate Model of Parkinsonism

Coordinated Reset Deep Brain Stimulation of Subthalamic Nucleus Produces Long-Lasting, Dose-Dependent Motor Improvements in the 1- Methyl -4- Phenyl -1,2,3,6-Tetrahydropyridine Non-Human Primate Model of Parkinsonism

Highlights • Intermittent, low-intensity coordinated reset (CR) deep brain stimulation (DBS) was observed to yield significant and persistent beneficial effects on motor signs in a non-human primate model of Parkinson's disease. • The magnitude and persistence of the therapeutic effects of CR D...

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Veröffentlicht in:Brain stimulation 2016-07, Vol.9 (4), p.609-617
Hauptverfasser: Wang, Jing, Nebeck, Shane, Muralidharan, Abirami, Johnson, Matthew D, Vitek, Jerrold L, Baker, Kenneth B
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Behavior, Animal
Coordinated reset
Deep brain stimulation
Deep Brain Stimulation - methods
Disease Models, Animal
Female
Macaca mulatta
MPTP
MPTP Poisoning
Neurology
Neuromodulation
Parkinson Disease, Secondary - chemically induced
Parkinson Disease, Secondary - therapy
Rhesus macaque
Subthalamic Nucleus
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Zusammenfassung:Highlights • Intermittent, low-intensity coordinated reset (CR) deep brain stimulation (DBS) was observed to yield significant and persistent beneficial effects on motor signs in a non-human primate model of Parkinson's disease. • The magnitude and persistence of the therapeutic effects of CR DBS were sensitive to daily treatment duration.
ISSN:1935-861X
1876-4754
DOI:10.1016/j.brs.2016.03.014