Successful Treatment of Prolonged, Severe Coronavirus Disease 2019 Lower Respiratory Tract Disease in a B cell Acute Lymphoblastic Leukemia Patient With an Extended Course of Remdesivir and Nirmatrelvir/Ritonavir
Abstract A patient with B-cell acute lymphoblastic leukemia (ALL) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had persistent, progressive pneumonia with viremia after 5 months of infection despite monoclonal antibodies, intravenous (IV) remdesivir and prolonged oral steroids. Tw...
Gespeichert in:
| Veröffentlicht in: | Clinical infectious diseases 2023-03, Vol.76 (5), p.926-929 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 929 |
|---|---|
| container_issue | 5 |
| container_start_page | 926 |
| container_title | Clinical infectious diseases |
| container_volume | 76 |
| creator | Ford, Emily S Simmons, William Karmarkar, Ellora N Yoke, Leah H Braimah, Ayodale B Orozco, Johnnie J Ghiuzeli, Cristina M Barnhill, Serena Sack, Coralynn L Benditt, Joshua O Roychoudhury, Pavitra Greninger, Alexander L Shapiro, Adrienne E Hammond, Jennifer L Rusnak, James M Dolsten, Mikael Boeckh, Michael Liu, Catherine Cheng, Guang-Shing Corey, Lawrence |
| description | Abstract
A patient with B-cell acute lymphoblastic leukemia (ALL) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had persistent, progressive pneumonia with viremia after 5 months of infection despite monoclonal antibodies, intravenous (IV) remdesivir and prolonged oral steroids. Twenty days of nirmatrelvir/ritonavir and 10 days of IV remdesivir led to full recovery. |
| doi_str_mv | 10.1093/cid/ciac868 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10226728</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/cid/ciac868</oup_id><sourcerecordid>2731717823</sourcerecordid><originalsourceid>FETCH-LOGICAL-c413t-4224dddf40a475033fe20e56083e453b60925711a2b86891a5f09f47933d6db63</originalsourceid><addsrcrecordid>eNp9kktv1DAUhSMEoqWwYo-8QkgQ6kfiOCtUhvKQIqimRSwtj33TMSRx8GNg_ic_CI9mGMGGhWXL_nTO0fUpiscEvyS4ZefamryUFlzcKU5JzZqS1y25m8-4FmUlmDgpHoTwFWNCBK7vFyeMM8q5wKfFr-ukNYTQpwHdeFBxhCki16Mr7wY33YJ5ga5hAx7Qwnk3qY31KaA3NoAKgCgmLercD_BoCWG2XkXnt1lJ6XiE7IQUeo00DAO60CkC6rbjvHarQYVoNeogfYPRKnSlot3Zf7FxjdSELn9GmAyYbJ18FsqxljAaCDanyIBBH60fVfQw5IvzpY37gA-Le70aAjw67GfF57eXN4v3Zffp3YfFRVfqirBYVpRWxpi-wqpqasxYDxRDzbFgUNVsxXFL64YQRVd5ti1RdY_bvmpaxgw3K87Oild73TmtRjA6Z_dqkLO3o_Jb6ZSV_75Mdi1v3UYSTClvqMgKzw4K3n1PEKIcbdgNSk3gUpC0YaQhjaAso8_3qPYuBA_90YdguSuCzEWQhyJk-snf0Y7sn5_PwNM94NL8X6Xft__AzQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2731717823</pqid></control><display><type>article</type><title>Successful Treatment of Prolonged, Severe Coronavirus Disease 2019 Lower Respiratory Tract Disease in a B cell Acute Lymphoblastic Leukemia Patient With an Extended Course of Remdesivir and Nirmatrelvir/Ritonavir</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Ford, Emily S ; Simmons, William ; Karmarkar, Ellora N ; Yoke, Leah H ; Braimah, Ayodale B ; Orozco, Johnnie J ; Ghiuzeli, Cristina M ; Barnhill, Serena ; Sack, Coralynn L ; Benditt, Joshua O ; Roychoudhury, Pavitra ; Greninger, Alexander L ; Shapiro, Adrienne E ; Hammond, Jennifer L ; Rusnak, James M ; Dolsten, Mikael ; Boeckh, Michael ; Liu, Catherine ; Cheng, Guang-Shing ; Corey, Lawrence</creator><creatorcontrib>Ford, Emily S ; Simmons, William ; Karmarkar, Ellora N ; Yoke, Leah H ; Braimah, Ayodale B ; Orozco, Johnnie J ; Ghiuzeli, Cristina M ; Barnhill, Serena ; Sack, Coralynn L ; Benditt, Joshua O ; Roychoudhury, Pavitra ; Greninger, Alexander L ; Shapiro, Adrienne E ; Hammond, Jennifer L ; Rusnak, James M ; Dolsten, Mikael ; Boeckh, Michael ; Liu, Catherine ; Cheng, Guang-Shing ; Corey, Lawrence</creatorcontrib><description>Abstract
A patient with B-cell acute lymphoblastic leukemia (ALL) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had persistent, progressive pneumonia with viremia after 5 months of infection despite monoclonal antibodies, intravenous (IV) remdesivir and prolonged oral steroids. Twenty days of nirmatrelvir/ritonavir and 10 days of IV remdesivir led to full recovery.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1093/cid/ciac868</identifier><identifier>PMID: 36326680</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Antiviral Agents - therapeutic use ; Brief Report ; COVID-19 ; COVID-19 Drug Treatment ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; Ritonavir - therapeutic use ; SARS-CoV-2</subject><ispartof>Clinical infectious diseases, 2023-03, Vol.76 (5), p.926-929</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-4224dddf40a475033fe20e56083e453b60925711a2b86891a5f09f47933d6db63</citedby><cites>FETCH-LOGICAL-c413t-4224dddf40a475033fe20e56083e453b60925711a2b86891a5f09f47933d6db63</cites><orcidid>0000-0001-7358-798X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36326680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ford, Emily S</creatorcontrib><creatorcontrib>Simmons, William</creatorcontrib><creatorcontrib>Karmarkar, Ellora N</creatorcontrib><creatorcontrib>Yoke, Leah H</creatorcontrib><creatorcontrib>Braimah, Ayodale B</creatorcontrib><creatorcontrib>Orozco, Johnnie J</creatorcontrib><creatorcontrib>Ghiuzeli, Cristina M</creatorcontrib><creatorcontrib>Barnhill, Serena</creatorcontrib><creatorcontrib>Sack, Coralynn L</creatorcontrib><creatorcontrib>Benditt, Joshua O</creatorcontrib><creatorcontrib>Roychoudhury, Pavitra</creatorcontrib><creatorcontrib>Greninger, Alexander L</creatorcontrib><creatorcontrib>Shapiro, Adrienne E</creatorcontrib><creatorcontrib>Hammond, Jennifer L</creatorcontrib><creatorcontrib>Rusnak, James M</creatorcontrib><creatorcontrib>Dolsten, Mikael</creatorcontrib><creatorcontrib>Boeckh, Michael</creatorcontrib><creatorcontrib>Liu, Catherine</creatorcontrib><creatorcontrib>Cheng, Guang-Shing</creatorcontrib><creatorcontrib>Corey, Lawrence</creatorcontrib><title>Successful Treatment of Prolonged, Severe Coronavirus Disease 2019 Lower Respiratory Tract Disease in a B cell Acute Lymphoblastic Leukemia Patient With an Extended Course of Remdesivir and Nirmatrelvir/Ritonavir</title><title>Clinical infectious diseases</title><addtitle>Clin Infect Dis</addtitle><description>Abstract
A patient with B-cell acute lymphoblastic leukemia (ALL) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had persistent, progressive pneumonia with viremia after 5 months of infection despite monoclonal antibodies, intravenous (IV) remdesivir and prolonged oral steroids. Twenty days of nirmatrelvir/ritonavir and 10 days of IV remdesivir led to full recovery.</description><subject>Antiviral Agents - therapeutic use</subject><subject>Brief Report</subject><subject>COVID-19</subject><subject>COVID-19 Drug Treatment</subject><subject>Humans</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</subject><subject>Ritonavir - therapeutic use</subject><subject>SARS-CoV-2</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kktv1DAUhSMEoqWwYo-8QkgQ6kfiOCtUhvKQIqimRSwtj33TMSRx8GNg_ic_CI9mGMGGhWXL_nTO0fUpiscEvyS4ZefamryUFlzcKU5JzZqS1y25m8-4FmUlmDgpHoTwFWNCBK7vFyeMM8q5wKfFr-ukNYTQpwHdeFBxhCki16Mr7wY33YJ5ga5hAx7Qwnk3qY31KaA3NoAKgCgmLercD_BoCWG2XkXnt1lJ6XiE7IQUeo00DAO60CkC6rbjvHarQYVoNeogfYPRKnSlot3Zf7FxjdSELn9GmAyYbJ18FsqxljAaCDanyIBBH60fVfQw5IvzpY37gA-Le70aAjw67GfF57eXN4v3Zffp3YfFRVfqirBYVpRWxpi-wqpqasxYDxRDzbFgUNVsxXFL64YQRVd5ti1RdY_bvmpaxgw3K87Oild73TmtRjA6Z_dqkLO3o_Jb6ZSV_75Mdi1v3UYSTClvqMgKzw4K3n1PEKIcbdgNSk3gUpC0YaQhjaAso8_3qPYuBA_90YdguSuCzEWQhyJk-snf0Y7sn5_PwNM94NL8X6Xft__AzQ</recordid><startdate>20230304</startdate><enddate>20230304</enddate><creator>Ford, Emily S</creator><creator>Simmons, William</creator><creator>Karmarkar, Ellora N</creator><creator>Yoke, Leah H</creator><creator>Braimah, Ayodale B</creator><creator>Orozco, Johnnie J</creator><creator>Ghiuzeli, Cristina M</creator><creator>Barnhill, Serena</creator><creator>Sack, Coralynn L</creator><creator>Benditt, Joshua O</creator><creator>Roychoudhury, Pavitra</creator><creator>Greninger, Alexander L</creator><creator>Shapiro, Adrienne E</creator><creator>Hammond, Jennifer L</creator><creator>Rusnak, James M</creator><creator>Dolsten, Mikael</creator><creator>Boeckh, Michael</creator><creator>Liu, Catherine</creator><creator>Cheng, Guang-Shing</creator><creator>Corey, Lawrence</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7358-798X</orcidid></search><sort><creationdate>20230304</creationdate><title>Successful Treatment of Prolonged, Severe Coronavirus Disease 2019 Lower Respiratory Tract Disease in a B cell Acute Lymphoblastic Leukemia Patient With an Extended Course of Remdesivir and Nirmatrelvir/Ritonavir</title><author>Ford, Emily S ; Simmons, William ; Karmarkar, Ellora N ; Yoke, Leah H ; Braimah, Ayodale B ; Orozco, Johnnie J ; Ghiuzeli, Cristina M ; Barnhill, Serena ; Sack, Coralynn L ; Benditt, Joshua O ; Roychoudhury, Pavitra ; Greninger, Alexander L ; Shapiro, Adrienne E ; Hammond, Jennifer L ; Rusnak, James M ; Dolsten, Mikael ; Boeckh, Michael ; Liu, Catherine ; Cheng, Guang-Shing ; Corey, Lawrence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-4224dddf40a475033fe20e56083e453b60925711a2b86891a5f09f47933d6db63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antiviral Agents - therapeutic use</topic><topic>Brief Report</topic><topic>COVID-19</topic><topic>COVID-19 Drug Treatment</topic><topic>Humans</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</topic><topic>Ritonavir - therapeutic use</topic><topic>SARS-CoV-2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ford, Emily S</creatorcontrib><creatorcontrib>Simmons, William</creatorcontrib><creatorcontrib>Karmarkar, Ellora N</creatorcontrib><creatorcontrib>Yoke, Leah H</creatorcontrib><creatorcontrib>Braimah, Ayodale B</creatorcontrib><creatorcontrib>Orozco, Johnnie J</creatorcontrib><creatorcontrib>Ghiuzeli, Cristina M</creatorcontrib><creatorcontrib>Barnhill, Serena</creatorcontrib><creatorcontrib>Sack, Coralynn L</creatorcontrib><creatorcontrib>Benditt, Joshua O</creatorcontrib><creatorcontrib>Roychoudhury, Pavitra</creatorcontrib><creatorcontrib>Greninger, Alexander L</creatorcontrib><creatorcontrib>Shapiro, Adrienne E</creatorcontrib><creatorcontrib>Hammond, Jennifer L</creatorcontrib><creatorcontrib>Rusnak, James M</creatorcontrib><creatorcontrib>Dolsten, Mikael</creatorcontrib><creatorcontrib>Boeckh, Michael</creatorcontrib><creatorcontrib>Liu, Catherine</creatorcontrib><creatorcontrib>Cheng, Guang-Shing</creatorcontrib><creatorcontrib>Corey, Lawrence</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ford, Emily S</au><au>Simmons, William</au><au>Karmarkar, Ellora N</au><au>Yoke, Leah H</au><au>Braimah, Ayodale B</au><au>Orozco, Johnnie J</au><au>Ghiuzeli, Cristina M</au><au>Barnhill, Serena</au><au>Sack, Coralynn L</au><au>Benditt, Joshua O</au><au>Roychoudhury, Pavitra</au><au>Greninger, Alexander L</au><au>Shapiro, Adrienne E</au><au>Hammond, Jennifer L</au><au>Rusnak, James M</au><au>Dolsten, Mikael</au><au>Boeckh, Michael</au><au>Liu, Catherine</au><au>Cheng, Guang-Shing</au><au>Corey, Lawrence</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful Treatment of Prolonged, Severe Coronavirus Disease 2019 Lower Respiratory Tract Disease in a B cell Acute Lymphoblastic Leukemia Patient With an Extended Course of Remdesivir and Nirmatrelvir/Ritonavir</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clin Infect Dis</addtitle><date>2023-03-04</date><risdate>2023</risdate><volume>76</volume><issue>5</issue><spage>926</spage><epage>929</epage><pages>926-929</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Abstract
A patient with B-cell acute lymphoblastic leukemia (ALL) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had persistent, progressive pneumonia with viremia after 5 months of infection despite monoclonal antibodies, intravenous (IV) remdesivir and prolonged oral steroids. Twenty days of nirmatrelvir/ritonavir and 10 days of IV remdesivir led to full recovery.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>36326680</pmid><doi>10.1093/cid/ciac868</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-7358-798X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2023-03, Vol.76 (5), p.926-929 |
| issn | 1058-4838 1537-6591 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10226728 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Antiviral Agents - therapeutic use Brief Report COVID-19 COVID-19 Drug Treatment Humans Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Ritonavir - therapeutic use SARS-CoV-2 |
| title | Successful Treatment of Prolonged, Severe Coronavirus Disease 2019 Lower Respiratory Tract Disease in a B cell Acute Lymphoblastic Leukemia Patient With an Extended Course of Remdesivir and Nirmatrelvir/Ritonavir |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T12%3A23%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Successful%20Treatment%20of%20Prolonged,%20Severe%20Coronavirus%20Disease%202019%20Lower%20Respiratory%20Tract%20Disease%20in%20a%20B%20cell%20Acute%20Lymphoblastic%20Leukemia%20Patient%20With%20an%20Extended%20Course%20of%20Remdesivir%20and%20Nirmatrelvir/Ritonavir&rft.jtitle=Clinical%20infectious%20diseases&rft.au=Ford,%20Emily%20S&rft.date=2023-03-04&rft.volume=76&rft.issue=5&rft.spage=926&rft.epage=929&rft.pages=926-929&rft.issn=1058-4838&rft.eissn=1537-6591&rft_id=info:doi/10.1093/cid/ciac868&rft_dat=%3Cproquest_pubme%3E2731717823%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2731717823&rft_id=info:pmid/36326680&rft_oup_id=10.1093/cid/ciac868&rfr_iscdi=true |