Successful Treatment of Prolonged, Severe Coronavirus Disease 2019 Lower Respiratory Tract Disease in a B cell Acute Lymphoblastic Leukemia Patient With an Extended Course of Remdesivir and Nirmatrelvir/Ritonavir

Abstract A patient with B-cell acute lymphoblastic leukemia (ALL) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had persistent, progressive pneumonia with viremia after 5 months of infection despite monoclonal antibodies, intravenous (IV) remdesivir and prolonged oral steroids. Tw...

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Veröffentlicht in:	Clinical infectious diseases 2023-03, Vol.76 (5), p.926-929
Hauptverfasser:	Ford, Emily S, Simmons, William, Karmarkar, Ellora N, Yoke, Leah H, Braimah, Ayodale B, Orozco, Johnnie J, Ghiuzeli, Cristina M, Barnhill, Serena, Sack, Coralynn L, Benditt, Joshua O, Roychoudhury, Pavitra, Greninger, Alexander L, Shapiro, Adrienne E, Hammond, Jennifer L, Rusnak, James M, Dolsten, Mikael, Boeckh, Michael, Liu, Catherine, Cheng, Guang-Shing, Corey, Lawrence
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - therapeutic use Brief Report COVID-19 COVID-19 Drug Treatment Humans Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Ritonavir - therapeutic use SARS-CoV-2
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Zusammenfassung:	Abstract A patient with B-cell acute lymphoblastic leukemia (ALL) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had persistent, progressive pneumonia with viremia after 5 months of infection despite monoclonal antibodies, intravenous (IV) remdesivir and prolonged oral steroids. Twenty days of nirmatrelvir/ritonavir and 10 days of IV remdesivir led to full recovery.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/ciac868