Effects of CFTR-modulator triple therapy on sinunasal symptoms in children and adults with cystic fibrosis

Purpose Sinunasal symptoms and chronic rhinusinutitis are common in patients with cystic fibrosis. Cystic fibrosis transmembrane regulator (CFTR) modulators have led to dramatic improvements of respiratory symptoms and quality of life in patients with cystic fibrosis. This study aims to evaluate sub...

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Veröffentlicht in:	European archives of oto-rhino-laryngology 2023-07, Vol.280 (7), p.3271-3277
Hauptverfasser:	Bode, Sebastian F. N., Rapp, Hannes, Lienert, Nadine, Appel, Heike, Fabricius, Dorit
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Benzodioxoles - therapeutic use Child Cystic Fibrosis - complications Cystic Fibrosis - drug therapy Cystic Fibrosis Transmembrane Conductance Regulator - genetics Emotions Head and Neck Surgery Humans Medicine Medicine & Public Health Mutation Neurosurgery Otorhinolaryngology Quality of Life Retrospective Studies Rhinology
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Beschreibung
Zusammenfassung:	Purpose Sinunasal symptoms and chronic rhinusinutitis are common in patients with cystic fibrosis. Cystic fibrosis transmembrane regulator (CFTR) modulators have led to dramatic improvements of respiratory symptoms and quality of life in patients with cystic fibrosis. This study aims to evaluate subjective and objective sinunasal symptoms after start of CFTR-modulator triple therapy. Methods 43 patients ( n = 6
ISSN:	0937-4477 1434-4726
DOI:	10.1007/s00405-023-07859-4