Insulin secretory actions of ethanolic extract of Acacia arabica bark in high fat-fed diet-induced obese Type 2 diabetic rats

Acacia arabica commonly known as 'babul' has been widely used for the treatment of numerous diseases, including diabetes due to their potential pharmacological actions. The aim of the present study was to investigate the insulinotropic and antidiabetic properties of ethanol extract of Acac...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioscience reports 2023-05, Vol.43 (5), p.1
Hauptverfasser:	Ansari, Prawej, Islam, Sara S, Akther, Samia, Khan, Joyeeta T, Shihab, Jaber A, Abdel-Wahab, Yasser H A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acacia - metabolism Acacia arabica Animals Anthraquinone Anthraquinones Antidiabetics Bark Beta cells Blood Glucose - metabolism Calcium (intracellular) Calcium ions Depolarization Diabetes Diabetes & Metabolic Disorders Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diet Dipeptidyl Peptidase 4 - metabolism Drug tolerance Endocrinology Enzymatic activity Enzyme activity Enzymes Ethanol Flavonoids Glucagon Glucagon-like peptide 1 Glucagon-Like Peptide 1 - metabolism Glucagon-Like Peptide 1 - pharmacology Glucagon-Like Peptide 1 - therapeutic use Glucose Glucose - metabolism Glucose diffusion Glucose tolerance Glycosylation Herbal medicine High fat diet Hyperglycemia Hypoglycemic Agents - therapeutic use In vivo methods and tests Insulin Insulin - metabolism Insulin resistance Insulin Secretion Membrane potential Metabolism Mice Mortality Obesity Obesity - drug therapy Obesity - metabolism Pharmacology & Toxicology Plant Bark - metabolism Potassium chloride Rats Secretion Therapeutics & Molecular Medicine Tolbutamide Verapamil
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Acacia arabica commonly known as 'babul' has been widely used for the treatment of numerous diseases, including diabetes due to their potential pharmacological actions. The aim of the present study was to investigate the insulinotropic and antidiabetic properties of ethanol extract of Acacia arabica (EEAA) bark through in vitro and in vivo studies in high fat-fed (HFF) rats. EEAA at 40-5000 µg/ml significantly increased (P
ISSN:	0144-8463 1573-4935
DOI:	10.1042/BSR20230329