Relationship between blood amyloid A and resting magnetic resonance functional brain connections in patients with obstructive sleep apnea–hypopnea syndrome

Objective The aim of this study was to analyze the relationship between serum amyloid A (SAA) concentrations in patients with obstructive sleep apnea–hypopnea syndrome (OSAHS) and their magnetic resonance imaging (MRI) of resting brain function. Methods Male patients with OSAHS were enrolled from January to June 2019 in Suzhou Ninth People’s Hospital Affiliated to Soochow University, and nineteen healthy male volunteers were selected as the normal control group. The patients with OSAHS were divided into mild, moderate, and severe groups according to their apnea-hypopnea index (AHI). Early in the morning after the polysomnography (PSG), blood samples were collected and serum levels of serum amyloid A (SAA) were measured by enzyme-linked immunosorbent assay. All subjects were scored by the Auditory Verbal Learning Test (AVLT) scale. Resting brain function images of healthy male volunteers and patients in the severe group were collected by 3.0 T magnetic resonance scanner. SPSS25.0 software was used for statistical analysis. Results The SAA of the OSAHS group ( n = 43) were higher than those of control group ( n = 19). The scores of AVLT-immediate and AVLT-delay in the severe OSAHS group were lower than those in the control group ( P