Predictors of atrial flutter recurrence after atrial fibrillation ablation: the crucial role of structural and morphological left atrial remodeling

Abstract Funding Acknowledgements Type of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): Unrestricted Grant - Abbott Medical Introduction Recurrence of supraventricular tachyarrhythmias after catheter ablation of atrial fibrillation (AF) is common, representing 30% of patients. Although AF recurrence occurs mostly, 10% of the patients face arrhythmia recurrence through atypical atrial flutter (AFL). The diagnostic and therapeutic management of atypical AFL is challenging. Predicting atypical AFL after AF catheter ablation is critical. Purpose To identify morphological and structural predictors of recurrence in the form of atypical AFL compared to AF based on Late Gadolinium Enhancement Cardiac Magnetic Resonance (LGE-CMR). Methods – From January 2013 to December 2021, 56 patients facing post AF-CA atypical AFL were included in the monocentric and retrospective cohort. 112 patients with AF recurrence were randomly included in the cohort from the general database. Pre-procedure LGE-CMR was post-processed for every patient to assess global and regional left and right atrial (LA, RA) fibrosis quantification using an image intensity ratio > 1.32 as fibrosis. Sphericity was calculated as the percentage of similarity with respect to a sphere, and the volume of LA and RA were calculated. Results – 168 patients who had faced supraventricular arrhythmia recurrence after AF-CA were included in the monocentric retrospective cohort. They were mainly male (72.1%), with a median CHADS-VASc score of 1.4 +/- 1.3, a number of previous CA of 2,2 +/- 0.4, and a biatrial dilation (LA volume index of 53.5 ml/m2, RA volume index of 59.6 ml/m2). An age superior to 65 (OR=6.61, CI95%:2.18-14.41, p