Higher In Vivo Fecal Concentrations of Clostridioides difficile Toxins A and B in Patients With North American Pulsed-Field Gel Electrophoresis Type 1/Ribotype 027 Strain Infection

Ultrasensitive, quantitative Clostridioides difficile stool toxin measurement demonstrated significantly higher concentrations of toxins A and B in patients infected with the North American pulsed-field gel electrophoresis type 1/ribotype 027 (NAP-1/027) strain compared with other strains, providing...

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Veröffentlicht in:	Clinical infectious diseases 2022-11, Vol.75 (11), p.2019-2022
Hauptverfasser:	Alonso, Carolyn D, Pollock, Nira R, Garey, Kevin W, Gonzales-Luna, Anne J, Williams, David N, Daugherty, Kaitlyn, Cuddemi, Christine, Villafuerte-Gálvez, Javier, White, Nicole C, Chen, Xinhua, Xu, Hua, Sprague, Rebecca, Barrett, Caitlin, Miller, Mark, Foussadier, Agnès, Lantz, Aude, Banz, Alice, Kelly, Ciarán P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Bacterial Bacterial Proteins - analysis Bacterial Proteins - genetics Bacterial Toxins - analysis Bacterial Toxins - genetics Brief Report Clostridioides difficile - genetics Clostridium Infections Electrophoresis, Gel, Pulsed-Field Enterotoxins - analysis Enterotoxins - genetics Feces - chemistry Humans North America Ribotyping
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Zusammenfassung:	Ultrasensitive, quantitative Clostridioides difficile stool toxin measurement demonstrated significantly higher concentrations of toxins A and B in patients infected with the North American pulsed-field gel electrophoresis type 1/ribotype 027 (NAP-1/027) strain compared with other strains, providing in vivo confirmation of the in vitro association between NAP-1/027 and elevated toxin production.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/ciac406