Digital microfluidics-based digital counting of single-cell copy number variation (dd-scCNV Seq)

Single-cell copy number variations (CNVs), major dynamic changes in humans, result in differential levels of gene expression and account for adaptive traits or underlying disease. Single-cell sequencing is needed to reveal these CNVs but has been hindered by single-cell whole-genome amplification (s...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-05, Vol.120 (20), p.e2221934120-e2221934120
Hauptverfasser:	Yu, Xiyuan, Ruan, Weidong, Lin, Fanghe, Qian, Weizhou, Zou, Yuan, Liu, Yilong, Su, Rui, Niu, Qi, Ruan, Qingyu, Lin, Wei, Zhu, Zhi, Zhang, Huimin, Yang, Chaoyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Biological Sciences Copy number Deoxyribonucleic acid DNA DNA Copy Number Variations - genetics Fragments Gene Dosage Gene expression Genomes High-Throughput Nucleotide Sequencing Humans Libraries Microfluidics Sequence Analysis, DNA - methods Single-Cell Analysis - methods Variation
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