First-Line Combination Treatment with Low-Dose Bipolar Drugs for ABCB1-Overexpressing Drug-Resistant Cancer Populations

Tumors include a heterogeneous population, of which a small proportion includes drug-resistant cancer (stem) cells. In drug-sensitive cancer populations, first-line chemotherapy reduces tumor volume via apoptosis. However, it stimulates drug-resistant cancer populations and finally results in tumor...

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Veröffentlicht in:International journal of molecular sciences 2023-05, Vol.24 (9), p.8389
Hauptverfasser: Yoon, Sungpil, Kim, Hyung Sik
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description Tumors include a heterogeneous population, of which a small proportion includes drug-resistant cancer (stem) cells. In drug-sensitive cancer populations, first-line chemotherapy reduces tumor volume via apoptosis. However, it stimulates drug-resistant cancer populations and finally results in tumor recurrence. Recurrent tumors are unresponsive to chemotherapeutic drugs and are primarily drug-resistant cancers. Therefore, increased apoptosis in drug-resistant cancer cells in heterogeneous populations is important in first-line chemotherapeutic treatments. The overexpression of ABCB1 (or P-gp) on cell membranes is an important characteristic of drug-resistant cancer cells; therefore, first-line combination treatments with P-gp inhibitors could delay tumor recurrence. Low doses of bipolar drugs showed P-gp inhibitory activity, and their use as a combined therapy sensitized drug-resistant cancer cells. FDA-approved bipolar drugs have been used in clinics for a long period of time, and their toxicities are well reported. They can be easily applied as first-line combination treatments for targeting resistant cancer populations. To apply bipolar drugs faster in first-line combination treatments, knowledge of their complete information is crucial. This review discusses the use of low-dose bipolar drugs in sensitizing ABCB1-overexpressing, drug-resistant cancers. We believe that this review will contribute to facilitating first-line combination treatments with low-dose bipolar drugs for targeting drug-resistant cancer populations. In addition, our findings may aid further investigations into targeting drug-resistant cancer populations with low-dose bipolar drugs.
doi_str_mv 10.3390/ijms24098389
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They can be easily applied as first-line combination treatments for targeting resistant cancer populations. To apply bipolar drugs faster in first-line combination treatments, knowledge of their complete information is crucial. This review discusses the use of low-dose bipolar drugs in sensitizing ABCB1-overexpressing, drug-resistant cancers. We believe that this review will contribute to facilitating first-line combination treatments with low-dose bipolar drugs for targeting drug-resistant cancer populations. In addition, our findings may aid further investigations into targeting drug-resistant cancer populations with low-dose bipolar drugs.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37176096</pmid><doi>10.3390/ijms24098389</doi><orcidid>https://orcid.org/0000-0002-9301-6313</orcidid><orcidid>https://orcid.org/0000-0001-7657-3970</orcidid><oa>free_for_read</oa></addata></record>
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subjects Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis
ATP Binding Cassette Transporter, Subfamily B - genetics
ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism
Blood-brain barrier
Breast cancer
Cancer
Cancer therapies
Cell cycle
Cell Line, Tumor
Cell membranes
Chemotherapy
Clinical trials
Cytotoxicity
Dopamine
Dosage and administration
Drug approval
Drug delivery
Drug dosages
Drug resistance
Drug Resistance, Neoplasm
Drug therapy
Drugs
Humans
Iloperidone
Kinases
Loxapine
Neoplasm Recurrence, Local
Populations
Psychotropic drugs
Radiation
Review
Thioridazine
Tumors
Vincristine
title First-Line Combination Treatment with Low-Dose Bipolar Drugs for ABCB1-Overexpressing Drug-Resistant Cancer Populations
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