Tamoxifen pharmacokinetics and pharmacodynamics in older patients with non-metastatic breast cancer

Background We aimed to study the pharmacokinetics and -dynamics of tamoxifen in older women with non-metastatic breast cancer. Methods Data for this analysis were derived from the CYPTAM study (NTR1509) database. Patients were stratified by age (age groups

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Veröffentlicht in:	Breast cancer research and treatment 2023-06, Vol.199 (3), p.471-478
Hauptverfasser:	Souwer, E. T. D., Sanchez-Spitman, A., Moes, D. J. A. R., Gelderblom, H., Swen, J. J., Portielje, J. E. A., Guchelaar, H. J., van Gelder, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age groups Aged patients Analysis Antineoplastic Agents, Hormonal - pharmacology Antineoplastic Agents, Hormonal - therapeutic use Bioavailability Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Cancer research Clinical Trial CYP2D6 protein CYP3A4 gene Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP3A - genetics Cytochrome P450 Female Gene polymorphism Genetic polymorphisms Genotype Genotyping Humans Medical research Medicine Medicine & Public Health Medicine, Experimental Metabolites Metastases Metastasis Oncology Patients Pharmacodynamics Pharmacokinetics Phenotypes Regression analysis Survival Tamoxifen Tamoxifen - pharmacology
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Zusammenfassung:	Background We aimed to study the pharmacokinetics and -dynamics of tamoxifen in older women with non-metastatic breast cancer. Methods Data for this analysis were derived from the CYPTAM study (NTR1509) database. Patients were stratified by age (age groups
ISSN:	0167-6806 1573-7217
DOI:	10.1007/s10549-023-06925-z