Clinical relevance and distribution of Helicobacter pylori virulence factors in isolates from Chinese patients

At present, the relationship between virulence factors of ( ) and gastrointestinal diseases is still under discussion. This study investigated the association between distinct virulence factors in and different gastrointestinal diseases. Gastric biopsy specimens were obtained from 160 patients with different gastrointestinal diseases in China, including 77 patients with chronic gastritis (CG), 36 with peptic ulcer disease (PUD), and 38 with gastric carcinoma (GC). The presence of certain virulence genes was determined by polymerase chain reaction (PCR), and the results were analyzed using chi-squared tests. A total of 160 strains were successfully isolated from gastric biopsy specimens. Overall, all strains of were , positive, and the most common genotypes were s1 (98.8%) and m2 (68.1%). The positive rates of the , , , , , and genes were 99.4%, 32.5%, 33.1%, 71.3%, 100%, and 6.9%, respectively. There was no significant association between these genes and different disease types. The dominant IIIR-positive genotype was detected in 83.1% of the strains, making it significantly more prevalent than the -positive genotype (P