Polyfunctional Antigen Specific CD4+ T cell Responses in Patients With Human Immunodeficiency Virus/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome

Abstract In the combination antiretroviral era, there are limited data regarding the pathogenesis of histoplasmosis immune reconstitution inflammatory syndrome (IRIS) in people with human immunodeficiency virus (HIV). We immunologically characterized 10 cases of histoplasmosis, 4 of whom developed h...

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Veröffentlicht in:	Clinical infectious diseases 2023-02, Vol.76 (3), p.531-534
Hauptverfasser:	Manion, Maura, Boulougoura, Afroditi, Naqvi, Nuha, Lage, Silvia Lucena, Richards, Elizabeth, Grivas, Christopher, Laidlaw, Elizabeth, Kuriakose, Safia, Ortega-Villa, Ana M, Tadros, Saber, Roby, Gregg, Rupert, Adam, Galindo, France, Anderson, Megan, Pau, Alice, Deepe, George, Sheikh, Virginia, Sereti, Irini
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - complications Brief Report CD4-Positive T-Lymphocytes Histoplasmosis HIV HIV Infections - complications HIV Infections - drug therapy Humans Immune Reconstitution Inflammatory Syndrome
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Zusammenfassung:	Abstract In the combination antiretroviral era, there are limited data regarding the pathogenesis of histoplasmosis immune reconstitution inflammatory syndrome (IRIS) in people with human immunodeficiency virus (HIV). We immunologically characterized 10 cases of histoplasmosis, 4 of whom developed histoplasmosis IRIS. CD4+ T cells in histoplasmosis IRIS demonstrated a significant polyfunctional cytokine response to histoplasma antigen.
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/ciac514