A role for lipophagy in atherosclerosis

Lipophagy is a type of selective autophagy that targets lipid droplets for degradation. Since the discovery of lipophagy in 2009, research has uncovered a central role for this process in cellular lipid metabolism, including in atherogenic foam cells. Therefore, increasing lipophagy might be a thera...

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Veröffentlicht in:	Nature reviews cardiology 2023-07, Vol.20 (7), p.431-432
Hauptverfasser:	Laval, Thomas, Ouimet, Mireille
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/287 692/699/75/593/2100 Atherosclerosis Autophagy Biosynthesis Cardiac Imaging Cardiac Surgery Cardiology Cells Cholesterol Comment Electron microscopes Humans Lipid Metabolism Lipids Medicine Medicine & Public Health Metabolism Proteins Recruitment Smooth muscle
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Beschreibung
Zusammenfassung:	Lipophagy is a type of selective autophagy that targets lipid droplets for degradation. Since the discovery of lipophagy in 2009, research has uncovered a central role for this process in cellular lipid metabolism, including in atherogenic foam cells. Therefore, increasing lipophagy might be a therapeutic target to reverse lipid build-up in atherosclerosis.
ISSN:	1759-5002 1759-5010
DOI:	10.1038/s41569-023-00885-z