An overview of SARS-CoV-2 transmission and engineering strategies to mitigate risk

The spread of the COVID-19 pandemic has profoundly affected every aspect of our lives. To date, experts have acknowledged that airborne transmission is a key piece of the SARS-CoV-2 puzzle. Nevertheless, the exact mechanism of airborne transmission of SARS-CoV-2 remains unclear. Recent works have shown the spreading of SARS-CoV-2 through numerical modeling and experimental works, but the successful applications of engineering approaches in reducing the spread of SARS-CoV-2 are lacking. In this review, the environmental factors that influence the transmission risk of SARS-CoV-2, such as ventilation flow rates, humidity, and temperature, are discussed. Besides, additional macro and micro weather factors, regional and global transmission, and the variants of the spread of SARS-CoV-2 are also reviewed. Engineering approaches that practically reduce the risks of SARS-CoV-2 transmissions are reported. Given the complex human behavior, environmental properties, and dynamic nature of the SARS-CoV-2 virus, it is reasonable to summarize that SARS-CoV-2 may not be eradicated even with the timely implementation of interventions. Therefore, more research exploring the potential cost-effective ways to control the transmission rate of SARS-CoV-2 may be a worthwhile pursuit to moderate the current crisis. •Airborne routes of SARS-CoV-2 are comprehensively summarized.•Good ventilation is the key to prevent indoor transmission of SARS-CoV-2.•Vertical displacement ventilation is effective to remove virus-laden aerosol indoor.•Applications of nanotechnology in preventive approach increases the effectiveness.•Wearing face mask significantly reduce indoor transmission risks.