Common analgesics and ovarian cancer survival: the Ovarian cancer Prognosis And Lifestyle (OPAL) Study

Common analgesics and ovarian cancer survival: the Ovarian cancer Prognosis And Lifestyle (OPAL) Study

Abstract Background Most women with ovarian cancer (OC) are diagnosed with advanced disease. They often experience recurrence after primary treatment, and their subsequent prognosis is poor. Our goal was to evaluate the association between use of nonsteroidal antiinflammatory drugs (NSAIDs), includi...

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Veröffentlicht in:JNCI : Journal of the National Cancer Institute 2023-05, Vol.115 (5), p.570-577
Hauptverfasser: Majidi, Azam, Na, Renhua, Jordan, Susan J, DeFazio, Anna, Obermair, Andreas, Friedlander, Michael, Grant, Peter, Webb, Penelope M
Format: Artikel
Sprache:eng
Schlagworte:
Acetaminophen
Acetaminophen - therapeutic use
Analgesics
Analgesics - therapeutic use
Anti-inflammatory agents
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Aspirin
Aspirin - therapeutic use
Australia - epidemiology
Cancer
Chemotherapy
Confidence intervals
Female
Humans
Medical prognosis
Nonsteroidal anti-inflammatory drugs
Ovarian cancer
Ovarian Neoplasms - drug therapy
Population studies
Prognosis
Proportional Hazards Models
Prospective Studies
Risk Factors
Self completed questionnaires
Statistical analysis
Survival
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Zusammenfassung:Abstract Background Most women with ovarian cancer (OC) are diagnosed with advanced disease. They often experience recurrence after primary treatment, and their subsequent prognosis is poor. Our goal was to evaluate the association between use of nonsteroidal antiinflammatory drugs (NSAIDs), including regular and low-dose aspirin, and 5-year cancer-specific survival after an OC diagnosis. Methods The Ovarian cancer Prognosis And Lifestyle study is a prospective population-based cohort of 958 Australian women with OC. Information was gathered through self-completed questionnaires. We classified NSAID use during the year prediagnosis and postdiagnosis as none or occasional (
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/djac239