Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS

Allogeneic hematopoietic stem cell transplantation remains the best curative option for higher-risk myelodysplastic syndrome. The presence of monosomal karyotype and/or complex karyotype abnormalities predicts inferior survival after allo-SCT in MDS patients. Haploidentical allo-SCT has been increas...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2023-05, Vol.58 (5), p.534-543
Hauptverfasser:	Michel, Claire, Robin, Marie, Morisset, Stephane, Blaise, Didier, Maertens, Johan, Chevalier, Patrice, Castilla-Llorente, Cristina, Forcade, Edouard, Ceballos, Patrice, Yakoug-Agha, Ibrahim, Poire, Xavier, Carre, Martin, Bay, Jacques-Olivier, Beguin, Yves, Loschi, Michael, Huynh, Anne, Guillerm, Gaëlle, François, Sylvie, Mear, Jean-Baptiste, Duléry, Rémy, Suarez, Felipe, Bilger, Karin, Cornillon, Jérôme, Chalandon, Yves, Maillard, Natacha, Labussière-Wallet, Hélène, Charbonnier, Amandine, Turlure, Pascal, Berceanu, Ana, Chantepie, Sylvain, Maury, Sébastien, Bazarbachi, Ali, Menard, Anne-Lise, Nguyen-Quoc, Stephanie, Rubio, Marie-Thérèse, D’Aveni, Maud
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 692/699 692/699/1541/1990/1673 Abnormalities Acute Disease Allografts Cell Biology Donors Graft vs Host Disease Graft vs Host Disease - etiology Graft-versus-host reaction Hematology Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cell Transplantation - methods Hematopoietic stem cells Histocompatibility antigen HLA Human health sciences Humans Hématologie Internal Medicine Karyotypes Leukemia Leukemia, Myeloid, Acute Leukemia, Myeloid, Acute - complications Life Sciences Medicine Medicine & Public Health Mud Myelodysplastic syndrome Myelodysplastic syndromes Public Health Retrospective Studies Risk Sciences de la santé humaine Siblings Stem cell transplantation Stem Cells Survival Tissue Donors Transplantation Transplantation Conditioning Transplantation Conditioning - methods Transplantation, Homologous Transplantation, Homologous - methods Unrelated Donors
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Zusammenfassung:	Allogeneic hematopoietic stem cell transplantation remains the best curative option for higher-risk myelodysplastic syndrome. The presence of monosomal karyotype and/or complex karyotype abnormalities predicts inferior survival after allo-SCT in MDS patients. Haploidentical allo-SCT has been increasingly used in acute leukemia (AL) and has similar results as using HLA-matched donors, but data on higher-risk MDS is sparse. We compared outcomes in 266 patients with higher-risk MDS after HLA-matched sibling donor (MSD, n = 79), HLA-matched unrelated donor (MUD, n = 139) and HLA haploidentical donor (HID, n = 48) from 2010 to 2019. Median donor age differed between the three groups ( p
ISSN:	0268-3369 1476-5365 1476-5365
DOI:	10.1038/s41409-023-01931-7