Parental age, genetic mutation, and cerebral palsy
Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations...
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| Veröffentlicht in: | Journal of medical genetics 1993-01, Vol.30 (1), p.44-46 |
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| container_title | Journal of medical genetics |
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| creator | Fletcher, N A Foley, J |
| description | Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation. |
| doi_str_mv | 10.1136/jmg.30.1.44 |
| format | Article |
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No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.</description><identifier>ISSN: 0022-2593</identifier><identifier>ISSN: 1468-6244</identifier><identifier>EISSN: 1468-6244</identifier><identifier>DOI: 10.1136/jmg.30.1.44</identifier><identifier>PMID: 8423607</identifier><identifier>CODEN: JMDGAE</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Adolescent ; Adult ; age ; Athetosis ; Biological and medical sciences ; Birth Order ; cerebral palsy ; Cerebral Palsy - classification ; Cerebral Palsy - genetics ; Cerebral Palsy - pathology ; Dystonia ; Genes, Dominant ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Hemiplegia ; Humans ; Infant, Newborn ; man ; Maternal Age ; Medical sciences ; Middle Aged ; Mutation ; Nervous system (semeiology, syndromes) ; Neurology ; Paralysis ; Paternal Age ; Quadriplegia</subject><ispartof>Journal of medical genetics, 1993-01, Vol.30 (1), p.44-46</ispartof><rights>1993 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Jan 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b533t-5636b9ce08a29c5b148cc0ef8501f1e2e9d4aa527417951e9e8dc4fe5d10ea913</citedby><cites>FETCH-LOGICAL-b533t-5636b9ce08a29c5b148cc0ef8501f1e2e9d4aa527417951e9e8dc4fe5d10ea913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1016233/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1016233/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,729,782,786,887,4026,27930,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4561328$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8423607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fletcher, N A</creatorcontrib><creatorcontrib>Foley, J</creatorcontrib><title>Parental age, genetic mutation, and cerebral palsy</title><title>Journal of medical genetics</title><addtitle>J Med Genet</addtitle><description>Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>age</subject><subject>Athetosis</subject><subject>Biological and medical sciences</subject><subject>Birth Order</subject><subject>cerebral palsy</subject><subject>Cerebral Palsy - classification</subject><subject>Cerebral Palsy - genetics</subject><subject>Cerebral Palsy - pathology</subject><subject>Dystonia</subject><subject>Genes, Dominant</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Hemiplegia</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>man</subject><subject>Maternal Age</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Paralysis</subject><subject>Paternal Age</subject><subject>Quadriplegia</subject><issn>0022-2593</issn><issn>1468-6244</issn><issn>1468-6244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1rFEEQxZtgiGuSk2dhwODFzNrV33MRwqKJsBpB47Xp6alZZ52PtXtGzH9vh102iQc9VcH78fpVP0KeA50DcPVm3a3mPO1zIQ7IDIQyuWJCPCEzShnLmSz4U_IsxjWlwDWoI3JkBOOK6hlhn13AfnRt5lZ4nq2wx7HxWTeNbmyG_jxzfZV5DFiGxGxcG29PyGGdJp7u5jG5ef_u6-IqX15fflhcLPNScj7mUnFVFh6pcazwsgRhvKdYG0mhBmRYVMI5ybQAXUjAAk3lRY2yAoquAH5M3m59N1PZYeVTzJTBbkLTuXBrB9fYx0rffLer4ZcFCopxngxe7QzC8HPCONquiR7b1vU4TNFqKQVjRv8XBCVAFZQl8OVf4HqYQp9-wYLWVBqm1V3w11vKhyHGgPU-M1B715hNjVmeditEol88PHPP7ipK-tlOd9G7tg6u903cY0KmF5lJWL7Fmjji773swg-rNNfSfvq2sPQjX14ZpeyX-5vLbv3PfH8AmhG4CA</recordid><startdate>199301</startdate><enddate>199301</enddate><creator>Fletcher, N A</creator><creator>Foley, J</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7T3</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199301</creationdate><title>Parental age, genetic mutation, and cerebral palsy</title><author>Fletcher, N A ; Foley, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b533t-5636b9ce08a29c5b148cc0ef8501f1e2e9d4aa527417951e9e8dc4fe5d10ea913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>age</topic><topic>Athetosis</topic><topic>Biological and medical sciences</topic><topic>Birth Order</topic><topic>cerebral palsy</topic><topic>Cerebral Palsy - classification</topic><topic>Cerebral Palsy - genetics</topic><topic>Cerebral Palsy - pathology</topic><topic>Dystonia</topic><topic>Genes, Dominant</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Hemiplegia</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>man</topic><topic>Maternal Age</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Paralysis</topic><topic>Paternal Age</topic><topic>Quadriplegia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fletcher, N A</creatorcontrib><creatorcontrib>Foley, J</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Human Genome Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of medical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fletcher, N A</au><au>Foley, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parental age, genetic mutation, and cerebral palsy</atitle><jtitle>Journal of medical genetics</jtitle><addtitle>J Med Genet</addtitle><date>1993-01</date><risdate>1993</risdate><volume>30</volume><issue>1</issue><spage>44</spage><epage>46</epage><pages>44-46</pages><issn>0022-2593</issn><issn>1468-6244</issn><eissn>1468-6244</eissn><coden>JMDGAE</coden><abstract>Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>8423607</pmid><doi>10.1136/jmg.30.1.44</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult age Athetosis Biological and medical sciences Birth Order cerebral palsy Cerebral Palsy - classification Cerebral Palsy - genetics Cerebral Palsy - pathology Dystonia Genes, Dominant Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hemiplegia Humans Infant, Newborn man Maternal Age Medical sciences Middle Aged Mutation Nervous system (semeiology, syndromes) Neurology Paralysis Paternal Age Quadriplegia |
| title | Parental age, genetic mutation, and cerebral palsy |
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