Parental age, genetic mutation, and cerebral palsy

Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations...

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Veröffentlicht in:	Journal of medical genetics 1993-01, Vol.30 (1), p.44-46
Hauptverfasser:	Fletcher, N A, Foley, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult age Athetosis Biological and medical sciences Birth Order cerebral palsy Cerebral Palsy - classification Cerebral Palsy - genetics Cerebral Palsy - pathology Dystonia Genes, Dominant Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hemiplegia Humans Infant, Newborn man Maternal Age Medical sciences Middle Aged Mutation Nervous system (semeiology, syndromes) Neurology Paralysis Paternal Age Quadriplegia
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Beschreibung
Zusammenfassung:	Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.
ISSN:	0022-2593 1468-6244 1468-6244
DOI:	10.1136/jmg.30.1.44