Fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae : Contributions of type II topoisomerase mutations and efflux to levels of resistance

We report on amino acid substitutions in the quinolone resistance-determining region of type II topisomerases and the prevalence of reserpine-inhibited efflux for 70 clinical isolates of S. pneumoniae for which the ciprofloxacin MIC is >/=4 microgram/ml and 28 isolates for which the ciprofloxacin...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2000-11, Vol.44 (11), p.3049-3054
Hauptverfasser:	BAST, Darrin J, LOW, Donald E, DUNCAN, Carla L, KILBURN, Laurie, MANDELL, Lionel A, DAVIDSON, Ross J, DE AZAVEDO, Joyce C. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Anti-Infective Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Proteins - genetics Bacterial Proteins - physiology Biological and medical sciences Biological Transport, Active Ciprofloxacin - pharmacology DNA Gyrase DNA Topoisomerase IV DNA Topoisomerases, Type II - genetics DNA Topoisomerases, Type II - physiology DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Drug Resistance, Microbial - genetics GyrA protein Humans Mechanisms of Resistance Medical sciences Microbial Sensitivity Tests ParC protein Pharmacology. Drug treatments Phenotype Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - enzymology Streptococcus pneumoniae - genetics
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Zusammenfassung:	We report on amino acid substitutions in the quinolone resistance-determining region of type II topisomerases and the prevalence of reserpine-inhibited efflux for 70 clinical isolates of S. pneumoniae for which the ciprofloxacin MIC is >/=4 microgram/ml and 28 isolates for which the ciprofloxacin MIC is
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.44.11.3049-3054.2000