Selected Approaches to Disrupting Protein-Protein Interactions within the MAPK/RAS Pathway

Selected Approaches to Disrupting Protein-Protein Interactions within the MAPK/RAS Pathway

Within the MAPK/RAS pathway, there exists a plethora of protein-protein interactions (PPIs). For many years, scientists have focused efforts on drugging KRAS and its effectors in hopes to provide much needed therapies for patients with -mutant driven cancers. In this review, we focus on recent strat...

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Veröffentlicht in:International journal of molecular sciences 2023-04, Vol.24 (8), p.7373
Hauptverfasser: Harwood, Stephen J, Smith, Christopher R, Lawson, J David, Ketcham, John M
Format: Artikel
Sprache:eng
Schlagworte:
Antimitotic agents
Antineoplastic agents
Cellular signal transduction
Humans
Mutation
Neoplasms - drug therapy
Neoplasms - genetics
Pharmaceutical industry
Proteins
Proto-Oncogene Proteins p21(ras) - genetics
Review
Signal Transduction
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Zusammenfassung:Within the MAPK/RAS pathway, there exists a plethora of protein-protein interactions (PPIs). For many years, scientists have focused efforts on drugging KRAS and its effectors in hopes to provide much needed therapies for patients with -mutant driven cancers. In this review, we focus on recent strategies to inhibit RAS-signaling via disrupting PPIs associated with SOS1, RAF, PDEδ, Grb2, and RAS.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms24087373