Accounting for diversity in the design and development of CRISPR-based therapeutic genome editing
CRISPR cell/gene therapy has been designed largely based on a single reference human genome. A new study reveals how human genetic diversity could lead to off-target effects and presents a novel tool to identify these risks.
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| Veröffentlicht in: | Nature genetics 2023-01, Vol.55 (1), p.6-7 |
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| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | CRISPR cell/gene therapy has been designed largely based on a single reference human genome. A new study reveals how human genetic diversity could lead to off-target effects and presents a novel tool to identify these risks. |
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| ISSN: | 1061-4036 1546-1718 |
| DOI: | 10.1038/s41588-022-01272-z |