Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer

Wu et al. report that patients with hematologic malignancies have reduced immunity against SARS-CoV-2 Omicron subvariants and Sotrovimab retains neutralizing capacity against all tested Omicron subvariants.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer cell 2023-05, Vol.41 (5), p.821-823
Hauptverfasser:	Wu, Mary Y., Shepherd, Scott T.C., Fendler, Annika, Carr, Edward J., Au, Lewis, Harvey, Ruth, Dowgier, Giulia, Hobbs, Agnieszka, Herman, Lou S., Ragno, Martina, Adams, Lorin, Schmitt, Andreas M., Tippu, Zayd, Shum, Benjamin, Farag, Sheima, Rogiers, Aljosja, O’Reilly, Nicola, Bawumia, Philip, Smith, Callie, Carlyle, Eleanor, Edmonds, Kim, Del Rosario, Lyra, Lingard, Karla, Mangwende, Mary, Holt, Lucy, Ahmod, Hamid, Korteweg, Justine, Foley, Tara, Barber, Taja, Hepworth, Stephanie, Emslie-Henry, Andrea, Caulfield-Lynch, Niamh, Byrne, Fiona, Deng, Daqi, Williams, Bryan, Brown, Michael, Caidan, Simon, Gavrielides, Mike, MacRae, James I., Kelly, Gavin, Peat, Kema, Kelly, Denise, Murra, Aida, Kelly, Kayleigh, O’Flaherty, Molly, Popat, Sanjay, Yousaf, Nadia, Jhanji, Shaman, Tatham, Kate, Cunningham, David, Van As, Nicholas, Young, Kate, Furness, Andrew J.S., Pickering, Lisa, Beale, Rupert, Swanton, Charles, Gandhi, Sonia, Gamblin, Steve, Bauer, David L.V., Kassiotis, George, Howell, Michael, Walker, Susanna, Nicholson, Emma, Larkin, James, Wall, Emma C., Turajlic, Samra
Format:	Artikel
Sprache:	eng
Schlagworte:	COVID-19 Hematologic Neoplasms - drug therapy Humans Letter Neoplasms SARS-CoV-2
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Wu et al. report that patients with hematologic malignancies have reduced immunity against SARS-CoV-2 Omicron subvariants and Sotrovimab retains neutralizing capacity against all tested Omicron subvariants.
ISSN:	1535-6108 1878-3686
DOI:	10.1016/j.ccell.2023.04.005