CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression. The spleen serves as an extra monocyte reservoir in inflammatory conditions; however, the precise mechanisms of involvement of the spleen in the p...

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Veröffentlicht in:Hepatology (Baltimore, Md.) Md.), 2023-05, Vol.77 (5), p.1612-1629
Hauptverfasser: Zhang, Shaoying, Wan, Dan, Zhu, Mengchen, Wang, Guihu, Zhang, Xurui, Huang, Na, Zhang, Jian, Zhang, Chongyu, Shang, Qi, Zhang, Chen, Liu, Xi, Liang, Fanfan, Zhang, Chunyan, Kong, Guangyao, Geng, Jing, Yao, Libo, Lu, Shemin, Chen, Yongyan, Li, Zongfang
Format: Artikel
Sprache:eng
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Original : Liver Failure/Cirrhosis/Portal Hypertension
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Zusammenfassung:Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression. The spleen serves as an extra monocyte reservoir in inflammatory conditions; however, the precise mechanisms of involvement of the spleen in the pathogenesis of liver fibrosis remain unclear.
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.32782