Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells

Scattered tubular cells (STCs) are a phenotypically distinct cell population in the proximal tubule that increase in number after acute kidney injury. We aimed to characterize the human STC population. Three‐dimensional human tissue analysis revealed that STCs are preferentially located within inner...

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Veröffentlicht in:	The Journal of pathology 2023-02, Vol.259 (2), p.149-162
Hauptverfasser:	Eymael, Jennifer, Broek, Martijn, Miesen, Laura, Monge, Valerie Villacorta, Berge, Bartholomeus T, Mooren, Fieke, Velez, Vicky Luna, Dijkstra, Jelmer, Hermsen, Meyke, Bándi, Péter, Vermeulen, Michiel, Wildt, Saskia, Willemsen, Brigith, Florquin, Sandrine, Wetzels, Roy, Steenbergen, Eric, Kramann, Rafael, Moeller, Marcus, Schreuder, Michiel F, Wetzels, Jack FM, Vlag, Johan, Jansen, Jitske, Smeets, Bart
Format:	Artikel
Sprache:	eng
Schlagworte:	(mal‐)adaptive repair Actin acute kidney injury Acute Kidney Injury - metabolism CD13 antigen Epithelial Cells Fibrosis Glycolysis Humans Inflammation Kidney - metabolism kidney regeneration Kidney Tubules, Proximal - pathology Kidneys Original Oxidative phosphorylation Phosphorylation proximal tubule scattered tubular cells Senescence Smooth muscle Transcriptomes Tricarboxylic acid cycle Tumor necrosis factor-α
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Zusammenfassung:	Scattered tubular cells (STCs) are a phenotypically distinct cell population in the proximal tubule that increase in number after acute kidney injury. We aimed to characterize the human STC population. Three‐dimensional human tissue analysis revealed that STCs are preferentially located within inner bends of the tubule and are barely present in young kidney tissue (
ISSN:	0022-3417 1096-9896
DOI:	10.1002/path.6029