Short-Lived Antibody-Mediated Saliva Immunity against SARS-CoV-2 after Vaccination

Short-Lived Antibody-Mediated Saliva Immunity against SARS-CoV-2 after Vaccination

Knowledge about the effect of vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on immunity reflected in the saliva is sparse. We examined the antibody response in saliva compared to that in serum 2 and 6 months after the first vaccination with the BNT162b2 vaccine. Fo...

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Veröffentlicht in:Microbiology spectrum 2023-03, Vol.11 (2), p.e0494722-e0494722
Hauptverfasser: Madsen, Johannes Roth, Holm, Bettina Eide, Pérez-Alós, Laura, Bayarri-Olmos, Rafael, Rosbjerg, Anne, Fogh, Kamille, Pries-Heje, Mia Marie, Møller, Dina Leth, Hansen, Cecilie Bo, Heftdal, Line Dam, Hasselbalch, Rasmus Bo, Hamm, Sebastian Rask, Frikke-Schmidt, Ruth, Hilsted, Linda, Nielsen, Susanne Dam, Iversen, Kasper Karmark, Bundgaard, Henning, Garred, Peter
Format: Artikel
Sprache:eng
Schlagworte:
Immunology
Research Article
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Zusammenfassung:Knowledge about the effect of vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on immunity reflected in the saliva is sparse. We examined the antibody response in saliva compared to that in serum 2 and 6 months after the first vaccination with the BNT162b2 vaccine. Four hundred fifty-nine health care professionals were included in a prospective observational study measuring antibody levels in saliva and corresponding serum samples at 2 and 6 months after BNT162b2 vaccination. Vaccinated, previously SARS-CoV-2-infected individuals (hybrid immunity) had higher IgG levels in saliva at 2 months than vaccinated, infection-naive individuals (  
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.04947-22