Effects of Intensive Systolic Blood Pressure Lowering on End-Stage Kidney Disease and Kidney Function Decline in Adults With Type 2 Diabetes Mellitus and Cardiovascular Risk Factors: A Post Hoc Analysis of ACCORD-BP and SPRINT

To determine the effects of intensive systolic blood pressure (SBP) lowering on the risk of major adverse kidney outcomes in people with type 2 diabetes mellitus (T2DM) and/or prediabetes and cardiovascular risk factors. This post hoc ACCORD-BP subgroup analysis included participants in the standard...

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Veröffentlicht in:	Diabetes care 2023-04, Vol.46 (4), p.868-873
Hauptverfasser:	Tawfik, Yahya M K, Van Tassell, Benjamin W, Dixon, Dave L, Baker, William L, Fanikos, John, Buckley, Leo F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antihypertensive Agents - therapeutic use Blood Pressure Cardiovascular diseases Cohort Studies Creatinine Design factors Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Dialysis End-stage renal disease Epidermal growth factor receptors Female Glomerular filtration rate Health hazards Health risks Humans Hypertension - drug therapy Kidney Kidney diseases Kidney Failure, Chronic Kidney transplantation Male Middle Aged Original Prediabetic State - drug therapy Regression analysis Regression models Research design Risk Factors Subgroups Treatment Outcome
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Zusammenfassung:	To determine the effects of intensive systolic blood pressure (SBP) lowering on the risk of major adverse kidney outcomes in people with type 2 diabetes mellitus (T2DM) and/or prediabetes and cardiovascular risk factors. This post hoc ACCORD-BP subgroup analysis included participants in the standard glucose-lowering arm with cardiovascular risk factors required for SPRINT eligibility. Cox proportional hazards regression models compared the hazard for the composite of dialysis, kidney transplant, sustained estimated glomerular filtration rate (eGFR) 3.3 mg/dL, or a sustained eGFR decline ≥57% between the intensive (
ISSN:	0149-5992 1935-5548
DOI:	10.2337/dc22-2040