Resting‐state functional alterations in patients with brain arteriovenous malformations involving language areas

Brain arteriovenous malformations (AVMs) may involve language areas but usually do not lead to aphasia. This study evaluated resting‐state functional alterations and investigated the language reorganization mechanism in AVM patients. Thirty‐nine patients with AVMs involving language areas and 32 age‐ and sex‐matched healthy controls were prospectively enrolled. The AVM patients were categorized into three subgroups according to lesion location: the frontal (15 patients), temporal (14 patients), and parietal subgroups (10 patients). All subjects underwent resting‐state functional magnetic resonance imaging (rs‐fMRI), and the amplitude of low‐frequency fluctuation (ALFF) approach was applied to analyze rs‐fMRI data. Language abilities were normal in all participants based on the Western Aphasia Battery. Compared with those of healthy subjects, ALFF values significantly increased (FDR corrected p