Early Antiretroviral Therapy Reduces Severity but Does Not Eliminate Neurodevelopmental Compromise in Children With HIV

Early Antiretroviral Therapy Reduces Severity but Does Not Eliminate Neurodevelopmental Compromise in Children With HIV

Early antiretroviral therapy (ART) during infancy reduces cognitive impairment due to HIV, but the extent of benefit is unclear. Children were recruited from hospital and health centers providing HIV care and treatment in Nairobi, Kenya. Cognitive, behavioral, and motor outcomes were assessed in chi...

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Veröffentlicht in:Journal of acquired immune deficiency syndromes (1999) 2023-05, Vol.93 (1), p.7-14
Hauptverfasser: Benki-Nugent, Sarah, Tamasha, Nancy, Mueni, Alice, Laboso, Tony, Wamalwa, Dalton C., Njuguna, Irene, Gómez, Laurén, Tapia, Kenneth, Bangirana, Paul, Maleche-Obimbo, Elizabeth, Boivin, Michael J., John-Stewart, Grace C.
Format: Artikel
Sprache:eng
Schlagworte:
Anti-HIV Agents - therapeutic use
Anti-Retroviral Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Child
Children
Cognition
Cognition & reasoning
Cognitive ability
Domains
Drug therapy
Executive function
HIV
HIV Infections - drug therapy
Human immunodeficiency virus
Humans
Impairment
Infant
Kenya
Memory
Motor skill
Motor task performance
Short term
Short term memory
Spatial memory
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Zusammenfassung:Early antiretroviral therapy (ART) during infancy reduces cognitive impairment due to HIV, but the extent of benefit is unclear. Children were recruited from hospital and health centers providing HIV care and treatment in Nairobi, Kenya. Cognitive, behavioral, and motor outcomes were assessed in children with HIV and early ART (
ISSN:1525-4135
1944-7884
DOI:10.1097/QAI.0000000000003165