Associations between estimates of perinatal industrial pollution exposures and intellectual disability in Utah children
While heavy metals exposure is associated with intellectual disability (ID), little is known about associations between industrial pollution and ID. The objective of this analysis is to assess associations between estimated perinatal industrial pollution exposures from the US Environmental Protectio...
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Veröffentlicht in: | The Science of the total environment 2022-08, Vol.836, p.155630-155630, Article 155630 |
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Sprache: | eng |
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Zusammenfassung: | While heavy metals exposure is associated with intellectual disability (ID), little is known about associations between industrial pollution and ID. The objective of this analysis is to assess associations between estimated perinatal industrial pollution exposures from the US Environmental Protection Agency's Risk Screening Environmental Indicators Microdata and children's ID risk. We conducted a case-control study of children born in Utah from 2000 to 2008 (n = 1679). Cases were identified through the Center for Disease Control's Autism and Developmental Disabilities Monitoring Network's Utah site and matched with controls based on birth year, sex, and birth county. We used multivariable generalized estimating equations to examine associations between estimated perinatal industrial pollution exposures and ID risk. The fourth quartile of industrial pollution exposure was associated with increased odds of ID relative to the first (Odds Ratio [OR]: 1.73, 95% Confidence Interval [CI]: 1.23–2.44) and second (OR: 1.67, CI: 1.19–2.35) quartiles. Similarly, the third quartile was associated with increased odds of ID relative to the first (OR: 1.47, CI: 1.06–2.03) and second (OR: 1.41, CI: 1.02–1.96) quartiles. Findings were robust to varied model specifications. Maternal residential exposures to industrial pollution were associated with increased ID prevalence in Utah. Since environmental correlates of ID are understudied, additional research is needed.
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•Environmental correlates of intellectual disability (ID) are under-examined.•We used a retrospective case-control study to examine industrial exposures and ID.•Industrial exposures at the maternal residential address were linked to ID in Utah.•Findings were robust to varied model specifications.•Findings provide a launching point for future research on this important topic. |
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ISSN: | 0048-9697 1879-1026 1879-1026 |
DOI: | 10.1016/j.scitotenv.2022.155630 |