An embarrassment of riches: RORγt+ antigen-presenting cells in peripheral tolerance

RORγt+ regulatory T (Treg) cells are critical toward maintaining gut immune tolerance. In recent studies published in Nature, Kedmi et al., Lyu et al., and Akagbosu et al. describe MHCII+RORγt+ antigen-presenting cells that mediate RORγt+ Treg cell differentiation but propose disparate identities fo...

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Veröffentlicht in:Immunity (Cambridge, Mass.) Mass.), 2022-11, Vol.55 (11), p.1978-1980
Hauptverfasser: Stephen-Victor, Emmanuel, Chatila, Talal A.
Format: Artikel
Sprache:eng
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Zusammenfassung:RORγt+ regulatory T (Treg) cells are critical toward maintaining gut immune tolerance. In recent studies published in Nature, Kedmi et al., Lyu et al., and Akagbosu et al. describe MHCII+RORγt+ antigen-presenting cells that mediate RORγt+ Treg cell differentiation but propose disparate identities for these cells. RORγt+ regulatory T (Treg) cells are critical toward maintaining gut immune tolerance. In recent studies published in Nature, Kedmi et al., Lyu et al., and Akagbosu et al. describe MHCII+RORγt+ antigen-presenting cells that mediate RORγt+ Treg cell differentiation but propose disparate identities for these cells.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2022.10.009