Neutrophil extracellular trap formation in anti-neutrophil cytoplasmic antibody-associated and large-vessel vasculitis

Levels of neutrophil extracellular traps (NETs) were measured in plasma of healthy controls (HC, n = 30) and patients with granulomatosis with polyangiitis (GPA, n = 123), microscopic polyangiitis (MPA, n = 61), Takayasu's arteritis (TAK, n = 58), and giant cell arteritis (GCA, n = 68), at time...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2023-04, Vol.249, p.109274-109274, Article 109274
Hauptverfasser:	Michailidou, Despina, Kuley, Runa, Wang, Ting, Hermanson, Payton, Grayson, Peter C., Cuthbertson, David, Khalidi, Nader A., Koening, Curry L., Langford, Carol A., McAlear, Carol A., Moreland, Larry W., Pagnoux, Christian, Seo, Philip, Specks, Ulrich, Sreih, Antoine G., Warrington, Kenneth J., Monach, Paul A., Merkel, Peter A., Lood, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Anti-neutrophil cytoplasmic antibody associated vasculitis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - drug therapy Case-Control Studies Child Extracellular Traps - metabolism Female Giant Cell Arteritis - metabolism Granulomatosis with Polyangiitis - metabolism Histone Humans Large vessel vasculitis Male Microscopic Polyangiitis - metabolism Middle Aged Neutrophil extracellular traps Neutrophils Platelet activation Takayasu Arteritis - metabolism Thrombospondin 1 - metabolism Thrombospondin-1
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Zusammenfassung:	Levels of neutrophil extracellular traps (NETs) were measured in plasma of healthy controls (HC, n = 30) and patients with granulomatosis with polyangiitis (GPA, n = 123), microscopic polyangiitis (MPA, n = 61), Takayasu's arteritis (TAK, n = 58), and giant cell arteritis (GCA, n = 68), at times of remission or activity and correlated with levels of the platelet-derived thrombospondin-1 (TSP-1). Levels of NETs were elevated during active disease in patients with GPA (p
ISSN:	1521-6616 1521-7035
DOI:	10.1016/j.clim.2023.109274