On-Demand, Reversible, Ultrasensitive Polymer Membrane Based on Molecular Imprinting Polymer

On-Demand, Reversible, Ultrasensitive Polymer Membrane Based on Molecular Imprinting Polymer

The development of in vivo, longitudinal, real-time monitoring devices is an essential step toward continuous, precision health monitoring. Molecularly imprinted polymers (MIPs) are popular sensor capture agents that are more robust than antibodies and have been used for sensors, drug delivery, affi...

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Veröffentlicht in:ACS nano 2023-03, Vol.17 (6), p.5632-5643
Hauptverfasser: Mintz Hemed, Nofar, Leal-Ortiz, Sergio, Zhao, Eric T., Melosh, Nicholas A.
Format: Artikel
Sprache:eng
Schlagworte:
Biosensing Techniques
Dopamine
Electrochemical Techniques
Molecular Imprinting
Polymers - chemistry
Povidone
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container_end_page 5643
container_issue 6
container_start_page 5632
container_title ACS nano
container_volume 17
creator Mintz Hemed, Nofar
Leal-Ortiz, Sergio
Zhao, Eric T.
Melosh, Nicholas A.
description The development of in vivo, longitudinal, real-time monitoring devices is an essential step toward continuous, precision health monitoring. Molecularly imprinted polymers (MIPs) are popular sensor capture agents that are more robust than antibodies and have been used for sensors, drug delivery, affinity separations, assays, and solid-phase extraction. However, MIP sensors are typically limited to one-time use due to their high binding affinity (>107 M–1) and slow-release kinetics (
doi_str_mv 10.1021/acsnano.2c11618
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We demonstrate an electrostatically refreshed dopamine sensor with a 760 pM limit of detection, linear response profile, and accuracy even after 30 sensing–release cycles. These sensors could repeatedly detect &lt;1 nM dopamine released from PC-12 cells in vitro, demonstrating they can longitudinally measure low concentrations in complex biological environments without clogging. 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source MEDLINE; American Chemical Society Publications
subjects Biosensing Techniques
Dopamine
Electrochemical Techniques
Molecular Imprinting
Polymers - chemistry
Povidone
title On-Demand, Reversible, Ultrasensitive Polymer Membrane Based on Molecular Imprinting Polymer
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