The Role of Rehabilitation in Arterial Function Properties of Convalescent COVID-19 Patients
Coronavirus disease (COVID-19) is a respiratory disease, although arterial function involvement has been documented. We assess the impact of a post-acute COVID-19 rehabilitation program on endothelium-dependent vasodilation and arterial wall properties. We enrolled 60 convalescent patients from COVI...
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Veröffentlicht in: | Journal of clinical medicine 2023-03, Vol.12 (6), p.2233 |
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Zusammenfassung: | Coronavirus disease (COVID-19) is a respiratory disease, although arterial function involvement has been documented. We assess the impact of a post-acute COVID-19 rehabilitation program on endothelium-dependent vasodilation and arterial wall properties. We enrolled 60 convalescent patients from COVID-19 and one-month post-acute disease, who were randomized at a 1:1 ratio in a 3-month cardiopulmonary rehabilitation program (study group) or not (control group). Endothelium-dependent vasodilation was evaluated by flow-mediated dilation (FMD), and arterial wall properties were evaluated by carotid-femoral pulse wave velocity (cf-PWV) and augmentation index (AIx) at 1 month and at 4 months post-acute disease. FMD was significantly improved in both the study (6.2 ± 1.8% vs. 8.6 ± 2.4%,
< 0.001) and control groups (5.9 ± 2.2% vs. 6.6 ± 1.8%,
= 0.009), but the improvement was significantly higher in the study group (rehabilitation) (
< 0.001). PWV was improved in the study group (8.2 ± 1.3 m/s vs. 6.6 ± 1.0 m/s,
< 0.001) but not in the control group (8.9 ± 1.8 m/s vs. 8.8 ± 1.9 m/s,
= 0.74). Similarly, AIx was improved in the study group (25.9 ± 9.8% vs. 21.1 ± 9.3%,
< 0.001) but not in the control group (27.6 ± 9.2% vs. 26.2 ± 9.8 m/s,
= 0.15). Convalescent COVID-19 subjects of the study group (rehabilitation) with increased serum levels of circulating IL-6 had a greater reduction in FMD. Conclusively, a 3-month cardiopulmonary post-acute COVID-19 rehabilitation program improves recovery of endothelium-dependent vasodilation and arteriosclerosis. |
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ISSN: | 2077-0383 2077-0383 |
DOI: | 10.3390/jcm12062233 |